IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v553y2018i7689d10.1038_nature25435.html
   My bibliography  Save this article

Regulation of embryonic haematopoietic multipotency by EZH1

Author

Listed:
  • Linda T. Vo

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute
    Harvard Medical School)

  • Melissa A. Kinney

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Xin Liu

    (Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center)

  • Yuannyu Zhang

    (Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
    Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Jessica Barragan

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Patricia M. Sousa

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Deepak K. Jha

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Areum Han

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Marcella Cesana

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Zhen Shao

    (Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Trista E. North

    (Beth Israel-Deaconess Medical Center)

  • Stuart H. Orkin

    (Boston Children’s Hospital and Dana Farber Cancer Institute
    Harvard Medical School
    Howard Hughes Medical Institute)

  • Sergei Doulatov

    (University of Washington)

  • Jian Xu

    (Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center)

  • George Q. Daley

    (Stem Cell Program, Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute
    Harvard Medical School)

Abstract

The production of haematopoietic stem cells is repressed during early mammalian embryogenesis by an epigenetic mechanism that involves the action of the Polycomb protein EZH1.

Suggested Citation

  • Linda T. Vo & Melissa A. Kinney & Xin Liu & Yuannyu Zhang & Jessica Barragan & Patricia M. Sousa & Deepak K. Jha & Areum Han & Marcella Cesana & Zhen Shao & Trista E. North & Stuart H. Orkin & Sergei , 2018. "Regulation of embryonic haematopoietic multipotency by EZH1," Nature, Nature, vol. 553(7689), pages 506-510, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25435
    DOI: 10.1038/nature25435
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25435
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25435?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wen Hao Neo & Yiran Meng & Alba Rodriguez-Meira & Muhammad Z. H. Fadlullah & Christopher A. G. Booth & Emanuele Azzoni & Supat Thongjuea & Marella F. T. R. Bruijn & Sten Eirik W. Jacobsen & Adam J. Me, 2021. "Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Carolina Gracia-Diaz & Yijing Zhou & Qian Yang & Reza Maroofian & Paula Espana-Bonilla & Chul-Hwan Lee & Shuo Zhang & Natàlia Padilla & Raquel Fueyo & Elisa A. Waxman & Sunyimeng Lei & Garrett Otrimsk, 2023. "Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Xia Chen & Peiliang Wang & Hui Qiu & Yonglin Zhu & Xingwu Zhang & Yaxuan Zhang & Fuyu Duan & Shuangyuan Ding & Jianying Guo & Yue Huang & Jie Na, 2022. "Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25435. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.