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A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

Author

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  • Carsten Bahr

    (German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    Faculty of Biosciences, University of Heidelberg)

  • Lisa von Paleske

    (German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    Faculty of Biosciences, University of Heidelberg)

  • Veli V. Uslu

    (Developmental Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Silvia Remeseiro

    (Developmental Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Naoya Takayama

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

  • Stanley W. Ng

    (Institute of Biomaterials and Biomedical Engineering, University of Toronto)

  • Alex Murison

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

  • Katja Langenfeld

    (Developmental Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Massimo Petretich

    (Developmental Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Roberta Scognamiglio

    (German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    Faculty of Biosciences, University of Heidelberg)

  • Petra Zeisberger

    (German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH))

  • Amelie S. Benk

    (German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    Faculty of Biosciences, University of Heidelberg)

  • Ido Amit

    (Weizmann Institute of Science)

  • Peter W. Zandstra

    (Institute of Biomaterials and Biomedical Engineering, University of Toronto
    The University of British Columbia)

  • Mathieu Lupien

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

  • John E. Dick

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

  • Andreas Trumpp

    (German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    Faculty of Biosciences, University of Heidelberg
    German Cancer Consortium (DKTK))

  • François Spitz

    (Developmental Biology Unit, European Molecular Biology Laboratory (EMBL)
    CNRS, UMR3738
    (Epi)genomics of Animal Development Unit)

Abstract

A blood enhancer cluster forms a highly combinatorial system that allows precise control of Myc expression across normal and leukaemic haematopoietic stem-cell hierarchies.

Suggested Citation

  • Carsten Bahr & Lisa von Paleske & Veli V. Uslu & Silvia Remeseiro & Naoya Takayama & Stanley W. Ng & Alex Murison & Katja Langenfeld & Massimo Petretich & Roberta Scognamiglio & Petra Zeisberger & Ame, 2018. "A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies," Nature, Nature, vol. 553(7689), pages 515-520, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25193
    DOI: 10.1038/nature25193
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    Citations

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    Cited by:

    1. Han Wang & Huiying Sun & Bilin Liang & Fang Zhang & Fan Yang & Bowen Cui & Lixia Ding & Xiang Wang & Ronghua Wang & Jiaoyang Cai & Yanjing Tang & Jianan Rao & Wenting Hu & Shuang Zhao & Wenyan Wu & Xi, 2023. "Chromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Laureano Tomás-Daza & Llorenç Rovirosa & Paula López-Martí & Andrea Nieto-Aliseda & François Serra & Ainoa Planas-Riverola & Oscar Molina & Rebecca McDonald & Cedric Ghevaert & Esther Cuatrecasas & Do, 2023. "Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Ning Qing Liu & Irene Paassen & Lars Custers & Peter Zeller & Hans Teunissen & Dilara Ayyildiz & Jiayou He & Juliane Laura Buhl & Eelco Wieger Hoving & Alexander Oudenaarden & Elzo Wit & Jarno Drost, 2023. "SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Sandra Kessler & Maryline Minoux & Onkar Joshi & Yousra Zouari & Sebastien Ducret & Fiona Ross & Nathalie Vilain & Adwait Salvi & Joachim Wolff & Hubertus Kohler & Michael B. Stadler & Filippo M. Rijl, 2023. "A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    5. Chaitali Chakraborty & Itzel Nissen & Craig A. Vincent & Anna-Carin Hägglund & Andreas Hörnblad & Silvia Remeseiro, 2023. "Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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