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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

Author

Listed:
  • Gannie Tzoneva

    (Institute for Cancer Genetics, Columbia University
    Regeneron Pharmaceuticals)

  • Chelsea L. Dieck

    (Institute for Cancer Genetics, Columbia University)

  • Koichi Oshima

    (Institute for Cancer Genetics, Columbia University)

  • Alberto Ambesi-Impiombato

    (Institute for Cancer Genetics, Columbia University
    PsychoGenics)

  • Marta Sánchez-Martín

    (Institute for Cancer Genetics, Columbia University)

  • Chioma J. Madubata

    (Columbia University)

  • Hossein Khiabanian

    (Rutgers Cancer Institute, Rutgers University)

  • Jiangyan Yu

    (Princess Maxima Center for Pediatric Oncology
    Radboud University Medical Center and Radboud Institute for Molecular Life Sciences)

  • Esme Waanders

    (Princess Maxima Center for Pediatric Oncology)

  • Ilaria Iacobucci

    (St. Jude Children’s Research Hospital)

  • Maria Luisa Sulis

    (Columbia University Medical Center)

  • Motohiro Kato

    (Saitama Children's Medical Center)

  • Katsuyoshi Koh

    (Saitama Children's Medical Center)

  • Maddalena Paganin

    (Salute della Donna e del Bambino (SDB), University of Padua)

  • Giuseppe Basso

    (Salute della Donna e del Bambino (SDB), University of Padua)

  • Julie M. Gastier-Foster

    (Nationwide Children’s Hospital
    Ohio State University School of Medicine
    Ohio State University School of Medicine
    Children’s Oncology Group)

  • Mignon L. Loh

    (University of California
    Helen Diller Family Comprehensive Cancer Center)

  • Renate Kirschner-Schwabe

    (Charité-Universitätsmedizin Berlin)

  • Charles G. Mullighan

    (St. Jude Children’s Research Hospital)

  • Raul Rabadan

    (Columbia University
    Columbia University)

  • Adolfo A. Ferrando

    (Institute for Cancer Genetics, Columbia University
    Columbia University
    Columbia University Medical Center
    Columbia University Medical Center)

Abstract

Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy.

Suggested Citation

  • Gannie Tzoneva & Chelsea L. Dieck & Koichi Oshima & Alberto Ambesi-Impiombato & Marta Sánchez-Martín & Chioma J. Madubata & Hossein Khiabanian & Jiangyan Yu & Esme Waanders & Ilaria Iacobucci & Maria , 2018. "Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia," Nature, Nature, vol. 553(7689), pages 511-514, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25186
    DOI: 10.1038/nature25186
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    Cited by:

    1. Amanda C. Lorentzian & Jenna Rever & Enes K. Ergin & Meiyun Guo & Neha M. Akella & Nina Rolf & C. James Lim & Gregor S. D. Reid & Christopher A. Maxwell & Philipp F. Lange, 2023. "Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Valentina Cordo’ & Mariska T. Meijer & Rico Hagelaar & Richard R. Goeij-de Haas & Vera M. Poort & Alex A. Henneman & Sander R. Piersma & Thang V. Pham & Koichi Oshima & Adolfo A. Ferrando & Guido J. R, 2022. "Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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