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Skin microbiota–host interactions

Author

Listed:
  • Y. Erin Chen

    (University of California San Francisco
    Stanford University)

  • Michael A. Fischbach

    (Stanford University)

  • Yasmine Belkaid

    (NIAID Microbiome Program, National Institute of Allergy and Infectious Disease, NIH
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, NIH)

Abstract

The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi and viruses. These microbes—collectively referred to as the skin microbiota—are fundamental to skin physiology and immunity. Interactions between skin microbes and the host can fall anywhere along the continuum between mutualism and pathogenicity. In this Review, we highlight how host–microbe interactions depend heavily on context, including the state of immune activation, host genetic predisposition, barrier status, microbe localization, and microbe–microbe interactions. We focus on how context shapes the complex dialogue between skin microbes and the host, and the consequences of this dialogue for health and disease.

Suggested Citation

  • Y. Erin Chen & Michael A. Fischbach & Yasmine Belkaid, 2018. "Skin microbiota–host interactions," Nature, Nature, vol. 553(7689), pages 427-436, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25177
    DOI: 10.1038/nature25177
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    Cited by:

    1. Tatsuya Dokoshi & Yang Chen & Kellen J. Cavagnero & Gibraan Rahman & Daniel Hakim & Samantha Brinton & Hana Schwarz & Elizabeth A. Brown & Alan O’Neill & Yoshiyuki Nakamura & Fengwu Li & Nita H. Salzm, 2024. "Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Tian-Yi Zhang & Yao-Qi Chen & Jing-Cong Tan & Jin-An Zhou & Wan-Ning Chen & Tong Jiang & Jin-Yin Zha & Xiang-Kang Zeng & Bo-Wen Li & Lu-Qi Wei & Yun Zou & Lu-Yao Zhang & Yue-Mei Hong & Xiu-Li Wang & R, 2024. "Global fungal-host interactome mapping identifies host targets of candidalysin," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Jianshi Jin & Reiko Yamamoto & Tadashi Takeuchi & Guangwei Cui & Eiji Miyauchi & Nozomi Hojo & Koichi Ikuta & Hiroshi Ohno & Katsuyuki Shiroguchi, 2022. "High-throughput identification and quantification of single bacterial cells in the microbiota," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Hannah Schünke & Ulrike Göbel & Ivan Dikic & Manolis Pasparakis, 2021. "OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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