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Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus

Author

Listed:
  • Romain Gibeaux

    (University of California, Berkeley)

  • Rachael Acker

    (University of California, Berkeley)

  • Maiko Kitaoka

    (University of California, Berkeley)

  • Georgios Georgiou

    (Radboud University, Faculty of Science, Radboud Institute for Molecular Life Sciences)

  • Ila van Kruijsbergen

    (Radboud University, Faculty of Science, Radboud Institute for Molecular Life Sciences)

  • Breanna Ford

    (University of California, Berkeley)

  • Edward M. Marcotte

    (Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin)

  • Daniel K. Nomura

    (University of California, Berkeley)

  • Taejoon Kwon

    (Ulsan National Institute of Science and Technology)

  • Gert Jan C. Veenstra

    (Radboud University, Faculty of Science, Radboud Institute for Molecular Life Sciences)

  • Rebecca Heald

    (University of California, Berkeley)

Abstract

In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death.

Suggested Citation

  • Romain Gibeaux & Rachael Acker & Maiko Kitaoka & Georgios Georgiou & Ila van Kruijsbergen & Breanna Ford & Edward M. Marcotte & Daniel K. Nomura & Taejoon Kwon & Gert Jan C. Veenstra & Rebecca Heald, 2018. "Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus," Nature, Nature, vol. 553(7688), pages 337-341, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7688:d:10.1038_nature25188
    DOI: 10.1038/nature25188
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