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Dietary trehalose enhances virulence of epidemic Clostridium difficile

Author

Listed:
  • J. Collins

    (Baylor College of Medicine, One Baylor Plaza)

  • C. Robinson

    (University of Oregon, Institute for Molecular Biology)

  • H. Danhof

    (Baylor College of Medicine, One Baylor Plaza)

  • C. W. Knetsch

    (Leiden University Medical Centre)

  • H. C. van Leeuwen

    (Leiden University Medical Centre)

  • T. D. Lawley

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • J. M. Auchtung

    (Baylor College of Medicine, One Baylor Plaza)

  • R. A. Britton

    (Baylor College of Medicine, One Baylor Plaza)

Abstract

Clostridium difficile disease has recently increased to become a dominant nosocomial pathogen in North America and Europe, although little is known about what has driven this emergence. Here we show that two epidemic ribotypes (RT027 and RT078) have acquired unique mechanisms to metabolize low concentrations of the disaccharide trehalose. RT027 strains contain a single point mutation in the trehalose repressor that increases the sensitivity of this ribotype to trehalose by more than 500-fold. Furthermore, dietary trehalose increases the virulence of a RT027 strain in a mouse model of infection. RT078 strains acquired a cluster of four genes involved in trehalose metabolism, including a PTS permease that is both necessary and sufficient for growth on low concentrations of trehalose. We propose that the implementation of trehalose as a food additive into the human diet, shortly before the emergence of these two epidemic lineages, helped select for their emergence and contributed to hypervirulence.

Suggested Citation

  • J. Collins & C. Robinson & H. Danhof & C. W. Knetsch & H. C. van Leeuwen & T. D. Lawley & J. M. Auchtung & R. A. Britton, 2018. "Dietary trehalose enhances virulence of epidemic Clostridium difficile," Nature, Nature, vol. 553(7688), pages 291-294, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7688:d:10.1038_nature25178
    DOI: 10.1038/nature25178
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    Cited by:

    1. Daniel P. G. H. Wong & Benjamin H. Good, 2024. "Quantifying the adaptive landscape of commensal gut bacteria using high-resolution lineage tracking," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Jordy Evan Sulaiman & Jaron Thompson & Yili Qian & Eugenio I. Vivas & Christian Diener & Sean M. Gibbons & Nasia Safdar & Ophelia S. Venturelli, 2024. "Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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