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Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

Author

Listed:
  • Gabriele Sulli

    (Regulatory Biology Laboratory, Salk Institute for Biological Studies)

  • Amy Rommel

    (Laboratory of Genetics, Salk Institute for Biological Studies)

  • Xiaojie Wang

    (University of California, Irvine)

  • Matthew J. Kolar

    (Clayton Foundation Laboratories of Peptide Biology, Salk Institute for Biological Studies)

  • Francesca Puca

    (The University of Texas MD, Anderson Cancer Center)

  • Alan Saghatelian

    (Clayton Foundation Laboratories of Peptide Biology, Salk Institute for Biological Studies)

  • Maksim V. Plikus

    (University of California, Irvine)

  • Inder M. Verma

    (Laboratory of Genetics, Salk Institute for Biological Studies)

  • Satchidananda Panda

    (Regulatory Biology Laboratory, Salk Institute for Biological Studies)

Abstract

REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo.

Suggested Citation

  • Gabriele Sulli & Amy Rommel & Xiaojie Wang & Matthew J. Kolar & Francesca Puca & Alan Saghatelian & Maksim V. Plikus & Inder M. Verma & Satchidananda Panda, 2018. "Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence," Nature, Nature, vol. 553(7688), pages 351-355, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7688:d:10.1038_nature25170
    DOI: 10.1038/nature25170
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    Cited by:

    1. Meghan H. Murray & Aurore Cecile Valfort & Thomas Koelblen & Céline Ronin & Fabrice Ciesielski & Arindam Chatterjee & Giri Babu Veerakanellore & Bahaa Elgendy & John K. Walker & Lamees Hegazy & Thomas, 2022. "Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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