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Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Author

Listed:
  • Xue Gao

    (Harvard University
    Howard Hughes Medical Institute, Harvard University
    Broad Institute of MIT and Harvard
    Rice University)

  • Yong Tao

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary
    Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Shanghai Ninth People’s Hospital and Ear Institute, Shanghai Jiaotong University School of Medicine)

  • Veronica Lamas

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary)

  • Mingqian Huang

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary)

  • Wei-Hsi Yeh

    (Harvard University
    Howard Hughes Medical Institute, Harvard University
    Broad Institute of MIT and Harvard
    Program in Speech and Hearing Bioscience and Technology, Harvard University)

  • Bifeng Pan

    (F.M. Kirby Neurobiology Center Boston Children’s Hospital and Harvard Medical School)

  • Yu-Juan Hu

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary
    Union Hospital, Tongji Medical College, Huazhong University of Science and Technology)

  • Johnny H. Hu

    (Harvard University
    Howard Hughes Medical Institute, Harvard University
    Broad Institute of MIT and Harvard)

  • David B. Thompson

    (Harvard University
    Howard Hughes Medical Institute, Harvard University)

  • Yilai Shu

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary
    Eye and ENT Hospital, Shanghai Medical College, Fudan University)

  • Yamin Li

    (Tufts University)

  • Hongyang Wang

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary
    Key Lab of Hearing Impairment Science of Ministry of Education, Key Lab of Hearing Impairment Prevention and Treatment of Beijing City, Chinese PLA Medical School)

  • Shiming Yang

    (Key Lab of Hearing Impairment Science of Ministry of Education, Key Lab of Hearing Impairment Prevention and Treatment of Beijing City, Chinese PLA Medical School)

  • Qiaobing Xu

    (Tufts University)

  • Daniel B. Polley

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary)

  • M. Charles Liberman

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary)

  • Wei-Jia Kong

    (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology)

  • Jeffrey R. Holt

    (F.M. Kirby Neurobiology Center Boston Children’s Hospital and Harvard Medical School)

  • Zheng-Yi Chen

    (Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary)

  • David R. Liu

    (Harvard University
    Howard Hughes Medical Institute, Harvard University
    Broad Institute of MIT and Harvard)

Abstract

CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.

Suggested Citation

  • Xue Gao & Yong Tao & Veronica Lamas & Mingqian Huang & Wei-Hsi Yeh & Bifeng Pan & Yu-Juan Hu & Johnny H. Hu & David B. Thompson & Yilai Shu & Yamin Li & Hongyang Wang & Shiming Yang & Qiaobing Xu & Da, 2018. "Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents," Nature, Nature, vol. 553(7687), pages 217-221, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7687:d:10.1038_nature25164
    DOI: 10.1038/nature25164
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    Cited by:

    1. Yong Tao & Veronica Lamas & Wan Du & Wenliang Zhu & Yiran Li & Madelynn N. Whittaker & John A. Zuris & David B. Thompson & Arun Prabhu Rameshbabu & Yilai Shu & Xue Gao & Johnny H. Hu & Charles Pei & W, 2023. "Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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