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Structure of the glucagon receptor in complex with a glucagon analogue

Author

Listed:
  • Haonan Zhang

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Anna Qiao

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Linlin Yang

    (School of Basic Medical Sciences, Zhengzhou University)

  • Ned Van Eps

    (University of Toronto)

  • Klaus S. Frederiksen

    (Novo Nordisk A/S, Novo Nordisk Park)

  • Dehua Yang

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Pudong)

  • Antao Dai

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Pudong)

  • Xiaoqing Cai

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Pudong)

  • Hui Zhang

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Cuiying Yi

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Can Cao

    (University of Chinese Academy of Sciences
    National Laboratory of Biomacromolecules, National Center of Protein Science - Beijing, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Lingli He

    (National Laboratory of Biomacromolecules, National Center of Protein Science - Beijing, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Huaiyu Yang

    (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University)

  • Jesper Lau

    (Novo Nordisk A/S, Novo Nordisk Park)

  • Oliver P. Ernst

    (University of Toronto
    University of Toronto, Toronto)

  • Michael A. Hanson

    (GPCR Consortium, San Marcos)

  • Raymond C. Stevens

    (iHuman Institute, ShanghaiTech University
    School of Life Science and Technology, ShanghaiTech University)

  • Ming-Wei Wang

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Pudong
    School of Life Science and Technology, ShanghaiTech University)

  • Steffen Reedtz-Runge

    (Novo Nordisk A/S, Novo Nordisk Park)

  • Hualiang Jiang

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Qiang Zhao

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences)

  • Beili Wu

    (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    School of Life Science and Technology, ShanghaiTech University
    CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences)

Abstract

The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.

Suggested Citation

  • Haonan Zhang & Anna Qiao & Linlin Yang & Ned Van Eps & Klaus S. Frederiksen & Dehua Yang & Antao Dai & Xiaoqing Cai & Hui Zhang & Cuiying Yi & Can Cao & Lingli He & Huaiyu Yang & Jesper Lau & Oliver P, 2018. "Structure of the glucagon receptor in complex with a glucagon analogue," Nature, Nature, vol. 553(7686), pages 106-110, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7686:d:10.1038_nature25153
    DOI: 10.1038/nature25153
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    Cited by:

    1. Xiuwen Zhai & Chunyou Mao & Qingya Shen & Shaokun Zang & Dan-Dan Shen & Huibing Zhang & Zhaohong Chen & Gang Wang & Changming Zhang & Yan Zhang & Zhihong Liu, 2022. "Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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