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Evolution of a designed protein assembly encapsulating its own RNA genome

Author

Listed:
  • Gabriel L. Butterfield

    (Institute for Protein Design, University of Washington
    University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington)

  • Marc J. Lajoie

    (Institute for Protein Design, University of Washington
    University of Washington)

  • Heather H. Gustafson

    (University of Washington
    Molecular Engineering and Sciences Institute, University of Washington)

  • Drew L. Sellers

    (University of Washington
    Molecular Engineering and Sciences Institute, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington)

  • Una Nattermann

    (Institute for Protein Design, University of Washington
    University of Washington
    Graduate Program in Biological Physics, Structure & Design, University of Washington)

  • Daniel Ellis

    (Institute for Protein Design, University of Washington
    University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington)

  • Jacob B. Bale

    (Institute for Protein Design, University of Washington
    University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington)

  • Sharon Ke

    (University of Washington)

  • Garreck H. Lenz

    (College of Arts & Sciences, University of Washington)

  • Angelica Yehdego

    (School of Public Health, University of Washington)

  • Rashmi Ravichandran

    (Institute for Protein Design, University of Washington
    University of Washington)

  • Suzie H. Pun

    (University of Washington
    Molecular Engineering and Sciences Institute, University of Washington)

  • Neil P. King

    (Institute for Protein Design, University of Washington
    University of Washington)

  • David Baker

    (Institute for Protein Design, University of Washington
    University of Washington
    Howard Hughes Medical Institute, University of Washington)

Abstract

Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

Suggested Citation

  • Gabriel L. Butterfield & Marc J. Lajoie & Heather H. Gustafson & Drew L. Sellers & Una Nattermann & Daniel Ellis & Jacob B. Bale & Sharon Ke & Garreck H. Lenz & Angelica Yehdego & Rashmi Ravichandran , 2017. "Evolution of a designed protein assembly encapsulating its own RNA genome," Nature, Nature, vol. 552(7685), pages 415-420, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7685:d:10.1038_nature25157
    DOI: 10.1038/nature25157
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    Cited by:

    1. Moses Fayiah & ShiKui Dong & Sphiwe Wezzie Khomera & Syed Aziz Ur Rehman & Mingyue Yang & Jiannan Xiao, 2020. "Status and Challenges of Qinghai–Tibet Plateau’s Grasslands: An Analysis of Causes, Mitigation Measures, and Way Forward," Sustainability, MDPI, vol. 12(3), pages 1-21, February.

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