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Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

Author

Listed:
  • Jiong Hu

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
    German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main)

  • Sarah Dziumbla

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
    German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main)

  • Jihong Lin

    (University Medicine Mannheim, University of Heidelberg)

  • Sofia-Iris Bibli

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
    German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main)

  • Sven Zukunft

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University)

  • Julian de Mos

    (Institute for Biophysical Chemistry and Centre for Biomolecular Magnetic Resonance, Goethe University)

  • Khader Awwad

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University)

  • Timo Frömel

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
    German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main)

  • Andreas Jungmann

    (Internal Medicine III, University Hospital Heidelberg
    German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim)

  • Kavi Devraj

    (Institute of Neurology (Edinger-Institute), Goethe University)

  • Zhixing Cheng

    (Henan Eye Institute & Henan Eye Hospital)

  • Liya Wang

    (Henan Eye Institute & Henan Eye Hospital)

  • Sascha Fauser

    (University Hospital of Cologne)

  • Charles G. Eberhart

    (Wilmer Eye Institute, Johns Hopkins School of Medicine)

  • Akrit Sodhi

    (Wilmer Eye Institute, Johns Hopkins School of Medicine)

  • Bruce D. Hammock

    (University of California, Davis)

  • Stefan Liebner

    (German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main
    Institute of Neurology (Edinger-Institute), Goethe University)

  • Oliver J. Müller

    (Internal Medicine III, University Hospital Heidelberg
    German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim
    University of Kiel)

  • Clemens Glaubitz

    (Institute for Biophysical Chemistry and Centre for Biomolecular Magnetic Resonance, Goethe University)

  • Hans-Peter Hammes

    (University Medicine Mannheim, University of Heidelberg)

  • Rüdiger Popp

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
    German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main)

  • Ingrid Fleming

    (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
    German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main)

Abstract

A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.

Suggested Citation

  • Jiong Hu & Sarah Dziumbla & Jihong Lin & Sofia-Iris Bibli & Sven Zukunft & Julian de Mos & Khader Awwad & Timo Frömel & Andreas Jungmann & Kavi Devraj & Zhixing Cheng & Liya Wang & Sascha Fauser & Cha, 2017. "Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy," Nature, Nature, vol. 552(7684), pages 248-252, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7684:d:10.1038_nature25013
    DOI: 10.1038/nature25013
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    Cited by:

    1. Thomas L. Maurissen & Alena J. Spielmann & Gabriella Schellenberg & Marc Bickle & Jose Ricardo Vieira & Si Ying Lai & Georgios Pavlou & Sascha Fauser & Peter D. Westenskow & Roger D. Kamm & Héloïse Ra, 2024. "Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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