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A non-canonical Notch complex regulates adherens junctions and vascular barrier function

Author

Listed:
  • William J. Polacheck

    (The Wyss Institute for Biologically Inspired Engineering, Harvard University
    Boston University)

  • Matthew L. Kutys

    (The Wyss Institute for Biologically Inspired Engineering, Harvard University
    Boston University)

  • Jinling Yang

    (The Wyss Institute for Biologically Inspired Engineering, Harvard University
    Boston University)

  • Jeroen Eyckmans

    (The Wyss Institute for Biologically Inspired Engineering, Harvard University
    Boston University)

  • Yinyu Wu

    (Yale Cardiovascular Research Center, Genetics, and Biomedical Engineering)

  • Hema Vasavada

    (Yale Cardiovascular Research Center, Genetics, and Biomedical Engineering)

  • Karen K. Hirschi

    (Yale Cardiovascular Research Center, Genetics, and Biomedical Engineering)

  • Christopher S. Chen

    (The Wyss Institute for Biologically Inspired Engineering, Harvard University
    Boston University)

Abstract

The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.

Suggested Citation

  • William J. Polacheck & Matthew L. Kutys & Jinling Yang & Jeroen Eyckmans & Yinyu Wu & Hema Vasavada & Karen K. Hirschi & Christopher S. Chen, 2017. "A non-canonical Notch complex regulates adherens junctions and vascular barrier function," Nature, Nature, vol. 552(7684), pages 258-262, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7684:d:10.1038_nature24998
    DOI: 10.1038/nature24998
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    Cited by:

    1. Torleif Tollefsrud Gjølberg & Jonas Aakre Wik & Hanna Johannessen & Stig Krüger & Nicola Bassi & Panagiotis F. Christopoulos & Malin Bern & Stian Foss & Goran Petrovski & Morten C. Moe & Guttorm Haral, 2023. "Antibody blockade of Jagged1 attenuates choroidal neovascularization," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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