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Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Author

Listed:
  • Fumiji Saito

    (Research Institute for Microbial Diseases, Osaka University, Suita)

  • Kouyuki Hirayasu

    (Laboratory of Immunochemistry, WPI Immunology Frontier Research Centre, Osaka University, Suita)

  • Takeshi Satoh

    (Research Institute for Microbial Diseases, Osaka University, Suita
    The University of Tokyo)

  • Christian W. Wang

    (Centre for Medical Parasitology, University of Copenhagen
    Copenhagen University Hospital (Rigshospitalet))

  • John Lusingu

    (National Institute for Medical Research, Tanga Research Centre)

  • Takao Arimori

    (Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University)

  • Kyoko Shida

    (Laboratory of Immunochemistry, WPI Immunology Frontier Research Centre, Osaka University, Suita)

  • Nirianne Marie Q. Palacpac

    (Research Institute for Microbial Diseases, Osaka University)

  • Sawako Itagaki

    (Research Institute for Microbial Diseases, Osaka University)

  • Shiroh Iwanaga

    (School of Medicine, Mie University
    Tokyo Medical and Dental University)

  • Eizo Takashima

    (Proteo-Science Centre, Ehime University)

  • Takafumi Tsuboi

    (Proteo-Science Centre, Ehime University)

  • Masako Kohyama

    (Research Institute for Microbial Diseases, Osaka University, Suita
    Laboratory of Immunochemistry, WPI Immunology Frontier Research Centre, Osaka University, Suita)

  • Tadahiro Suenaga

    (Research Institute for Microbial Diseases, Osaka University, Suita
    Laboratory of Immunochemistry, WPI Immunology Frontier Research Centre, Osaka University, Suita)

  • Marco Colonna

    (Washington University School of Medicine)

  • Junichi Takagi

    (Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University)

  • Thomas Lavstsen

    (Centre for Medical Parasitology, University of Copenhagen
    Copenhagen University Hospital (Rigshospitalet))

  • Toshihiro Horii

    (Research Institute for Microbial Diseases, Osaka University)

  • Hisashi Arase

    (Research Institute for Microbial Diseases, Osaka University, Suita
    Laboratory of Immunochemistry, WPI Immunology Frontier Research Centre, Osaka University, Suita)

Abstract

Proteins expressed on the surfaces of erythrocytes infected with Plasmodium falciparum help the parasite to evade the host immune system by acting as ligands for immune inhibitory receptors and thereby downregulating the immune response.

Suggested Citation

  • Fumiji Saito & Kouyuki Hirayasu & Takeshi Satoh & Christian W. Wang & John Lusingu & Takao Arimori & Kyoko Shida & Nirianne Marie Q. Palacpac & Sawako Itagaki & Shiroh Iwanaga & Eizo Takashima & Takaf, 2017. "Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors," Nature, Nature, vol. 552(7683), pages 101-105, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24994
    DOI: 10.1038/nature24994
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    Cited by:

    1. Marvin Chew & Weijian Ye & Radoslaw Igor Omelianczyk & Charisse Flerida Pasaje & Regina Hoo & Qingfeng Chen & Jacquin C. Niles & Jianzhu Chen & Peter Preiser, 2022. "Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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