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Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Author

Listed:
  • Giovanni Germano

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Simona Lamba

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Giuseppe Rospo

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Ludovic Barault

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Alessandro Magrì

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Federica Maione

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Mariangela Russo

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Giovanni Crisafulli

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Alice Bartolini

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Giulia Lerda

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Giulia Siravegna

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Benedetta Mussolin

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Roberta Frapolli

    (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri)

  • Monica Montone

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Federica Morano

    (Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Filippo de Braud

    (Fondazione IRCCS Istituto Nazionale dei Tumori
    Department of Oncology and Hemat-Oncology Università degli Studi di Milano)

  • Nabil Amirouchene-Angelozzi

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    FIRC Institute of Molecular Oncology (IFOM))

  • Silvia Marsoni

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo)

  • Maurizio D’Incalci

    (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri)

  • Armando Orlandi

    (Policlinico Universitario A. Gemelli)

  • Enrico Giraudo

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Torino)

  • Andrea Sartore-Bianchi

    (Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda)

  • Salvatore Siena

    (Department of Oncology and Hemat-Oncology Università degli Studi di Milano
    Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda)

  • Filippo Pietrantonio

    (Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Federica Di Nicolantonio

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

  • Alberto Bardelli

    (Candiolo Cancer Institute – FPO, IRCCS, Candiolo
    University of Turin, Candiolo)

Abstract

The inactivation of DNA mismatch repair in cancer cells produces dynamic mutational profiles and generates neoantigens, which result in improved immune surveillance against these cells.

Suggested Citation

  • Giovanni Germano & Simona Lamba & Giuseppe Rospo & Ludovic Barault & Alessandro Magrì & Federica Maione & Mariangela Russo & Giovanni Crisafulli & Alice Bartolini & Giulia Lerda & Giulia Siravegna & B, 2017. "Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth," Nature, Nature, vol. 552(7683), pages 116-120, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24673
    DOI: 10.1038/nature24673
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    Cited by:

    1. Yajie Sun & Jeffrey Patterson-Fortin & Sen Han & Zhe Li & Zuzanna Nowicka & Yuna Hirohashi & Susan Kilgas & Jae Kyo Yi & Alexander Spektor & Wojciech Fendler & Panagiotis A. Konstantinopoulos & Dipanj, 2024. "53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Han-Ying Huang & Yan-Zhou Chen & Chuang Zhao & Xin-Nan Zheng & Kai Yu & Jia-Xing Yue & Huai-Qiang Ju & Yan-Xia Shi & Lin Tian, 2024. "Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Lucía López & Luciano Gastón Morosi & Federica Terza & Pierre Bourdely & Giuseppe Rospo & Roberto Amadio & Giulia Maria Piperno & Valentina Russo & Camilla Volponi & Simone Vodret & Sonal Joshi & Fran, 2024. "Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Qiaoqi Sui & Xi Zhang & Chao Chen & Jinghua Tang & Jiehai Yu & Weihao Li & Kai Han & Wu Jiang & Leen Liao & Lingheng Kong & Yuan Li & Zhenlin Hou & Chi Zhou & Chenzhi Zhang & Linjie Zhang & Binyi Xiao, 2022. "Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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