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PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

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  • Tim Wartewig

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München)

  • Zsuzsanna Kurgyis

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München)

  • Selina Keppler

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München)

  • Konstanze Pechloff

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München
    German Cancer Consortium (DKTK))

  • Erik Hameister

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München)

  • Rupert Öllinger

    (TranslaTUM, Center for Translational Cancer Research, Technische Universität München
    Klinikum Rechts der Isar, Technische Universität München)

  • Roman Maresch

    (TranslaTUM, Center for Translational Cancer Research, Technische Universität München
    Klinikum Rechts der Isar, Technische Universität München)

  • Thorsten Buch

    (Institute of Laboratory Animal Science, University of Zurich)

  • Katja Steiger

    (Institute of Pathology, Technische Universität München)

  • Christof Winter

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München
    German Cancer Consortium (DKTK))

  • Roland Rad

    (TranslaTUM, Center for Translational Cancer Research, Technische Universität München
    German Cancer Consortium (DKTK)
    Klinikum Rechts der Isar, Technische Universität München)

  • Jürgen Ruland

    (Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München
    TranslaTUM, Center for Translational Cancer Research, Technische Universität München
    German Cancer Consortium (DKTK)
    German Center for Infection Research (DZIF))

Abstract

Loss of the PD-1 receptor promotes the development of T cell non-Hodgkin lymphomas by modulating oncogenic signalling pathways, and blocking these pathways reduces tumourigenesis.

Suggested Citation

  • Tim Wartewig & Zsuzsanna Kurgyis & Selina Keppler & Konstanze Pechloff & Erik Hameister & Rupert Öllinger & Roman Maresch & Thorsten Buch & Katja Steiger & Christof Winter & Roland Rad & Jürgen Ruland, 2017. "PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis," Nature, Nature, vol. 552(7683), pages 121-125, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24649
    DOI: 10.1038/nature24649
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