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A semi-synthetic organism that stores and retrieves increased genetic information

Author

Listed:
  • Yorke Zhang

    (The Scripps Research Institute)

  • Jerod L. Ptacin

    (Synthorx, Inc.)

  • Emil C. Fischer

    (The Scripps Research Institute)

  • Hans R. Aerni

    (Synthorx, Inc.)

  • Carolina E. Caffaro

    (Synthorx, Inc.)

  • Kristine San Jose

    (Synthorx, Inc.)

  • Aaron W. Feldman

    (The Scripps Research Institute)

  • Court R. Turner

    (Synthorx, Inc.)

  • Floyd E. Romesberg

    (The Scripps Research Institute)

Abstract

A modified Escherichia coli is used to demonstrate that semi-synthetic organisms can use non-natural hydrophobic base pairs to genetically encode for the incorporation of non-canonical amino acids into proteins.

Suggested Citation

  • Yorke Zhang & Jerod L. Ptacin & Emil C. Fischer & Hans R. Aerni & Carolina E. Caffaro & Kristine San Jose & Aaron W. Feldman & Court R. Turner & Floyd E. Romesberg, 2017. "A semi-synthetic organism that stores and retrieves increased genetic information," Nature, Nature, vol. 551(7682), pages 644-647, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7682:d:10.1038_nature24659
    DOI: 10.1038/nature24659
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    Cited by:

    1. Bang Wang & Kevin M. Bradley & Myong-Jung Kim & Roberto Laos & Cen Chen & Dietlind L. Gerloff & Luran Manfio & Zunyi Yang & Steven A. Benner, 2024. "Enzyme-assisted high throughput sequencing of an expanded genetic alphabet at single base resolution," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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