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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Author

Listed:
  • Jun Xu

    (Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego)

  • Indrajit Lahiri

    (School of Medicine, University of California San Diego)

  • Wei Wang

    (Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego)

  • Adam Wier

    (School of Medicine, University of California San Diego)

  • Michael A. Cianfrocco

    (School of Medicine, University of California San Diego
    University of Michigan)

  • Jenny Chong

    (Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego)

  • Alissa A. Hare

    (California Institute of Technology)

  • Peter B. Dervan

    (California Institute of Technology)

  • Frank DiMaio

    (University of Washington)

  • Andres E. Leschziner

    (School of Medicine, University of California San Diego
    Section of Molecular Biology, University of California San Diego)

  • Dong Wang

    (Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego
    School of Medicine, University of California San Diego)

Abstract

Cryo-electron microscopy analysis of yeast Rad26 bound to RNA polymerase II provides insight into the initiation of the transcription-coupled DNA repair mechanism in eukaryotes.

Suggested Citation

  • Jun Xu & Indrajit Lahiri & Wei Wang & Adam Wier & Michael A. Cianfrocco & Jenny Chong & Alissa A. Hare & Peter B. Dervan & Frank DiMaio & Andres E. Leschziner & Dong Wang, 2017. "Structural basis for the initiation of eukaryotic transcription-coupled DNA repair," Nature, Nature, vol. 551(7682), pages 653-657, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7682:d:10.1038_nature24658
    DOI: 10.1038/nature24658
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    Cited by:

    1. Chunli Yan & Thomas Dodd & Jina Yu & Bernice Leung & Jun Xu & Juntaek Oh & Dong Wang & Ivaylo Ivanov, 2021. "Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Barbara Steurer & Roel C. Janssens & Marit E. Geijer & Fernando Aprile-Garcia & Bart Geverts & Arjan F. Theil & Barbara Hummel & Martin E. Royen & Bastiaan Evers & René Bernards & Adriaan B. Houtsmull, 2022. "DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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