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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Author

Listed:
  • Samantha W. Alvarez

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine)

  • Vladislav O. Sviderskiy

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine)

  • Erdem M. Terzi

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine)

  • Thales Papagiannakopoulos

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine)

  • Andre L. Moreira

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine)

  • Sylvia Adams

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research
    Massachusetts Institute of Technology)

  • Kıvanç Birsoy

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research
    Massachusetts Institute of Technology)

  • Richard Possemato

    (New York University School of Medicine
    Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
    Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.

Suggested Citation

  • Samantha W. Alvarez & Vladislav O. Sviderskiy & Erdem M. Terzi & Thales Papagiannakopoulos & Andre L. Moreira & Sylvia Adams & David M. Sabatini & Kıvanç Birsoy & Richard Possemato, 2017. "NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis," Nature, Nature, vol. 551(7682), pages 639-643, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7682:d:10.1038_nature24637
    DOI: 10.1038/nature24637
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    Cited by:

    1. Nathan P. Ward & Sang Jun Yoon & Tyce Flynn & Amanda M. Sherwood & Maddison A. Olley & Juliana Madej & Gina M. DeNicola, 2024. "Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Dadi Jiang & Youming Guo & Tianyu Wang & Liang Wang & Yuelong Yan & Ling Xia & Rakesh Bam & Zhifen Yang & Hyemin Lee & Takao Iwawaki & Boyi Gan & Albert C. Koong, 2024. "IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Bartosz Wiernicki & Sophia Maschalidi & Jonathan Pinney & Sandy Adjemian & Tom Vanden Berghe & Kodi S. Ravichandran & Peter Vandenabeele, 2022. "Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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