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A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

Author

Listed:
  • Marta Łuksza

    (The Simons Center for Systems Biology, Institute for Advanced Study)

  • Nadeem Riaz

    (Memorial Sloan Kettering Cancer Center
    Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center)

  • Vladimir Makarov

    (Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Vinod P. Balachandran

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center)

  • Matthew D. Hellmann

    (Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College, Cornell University)

  • Alexander Solovyov

    (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
    Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Naiyer A. Rizvi

    (Columbia University Medical Center)

  • Taha Merghoub

    (Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
    Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center
    Melanoma and Immunotherapeutics Service, Memorial Sloan Kettering Cancer Center)

  • Arnold J. Levine

    (The Simons Center for Systems Biology, Institute for Advanced Study)

  • Timothy A. Chan

    (Memorial Sloan Kettering Cancer Center
    Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center)

  • Jedd D. Wolchok

    (Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center
    Melanoma and Immunotherapeutics Service, Memorial Sloan Kettering Cancer Center)

  • Benjamin D. Greenbaum

    (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
    Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

Abstract

An immune fitness model for tumours under checkpoint blockade immunotherapy is proposed, through which the authors show that the presentation and recognition properties of dominant neoantigens distributed over tumour subclones are predictive of response in melanoma and lung cancer cohorts.

Suggested Citation

  • Marta Łuksza & Nadeem Riaz & Vladimir Makarov & Vinod P. Balachandran & Matthew D. Hellmann & Alexander Solovyov & Naiyer A. Rizvi & Taha Merghoub & Arnold J. Levine & Timothy A. Chan & Jedd D. Wolcho, 2017. "A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy," Nature, Nature, vol. 551(7681), pages 517-520, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7681:d:10.1038_nature24473
    DOI: 10.1038/nature24473
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    Cited by:

    1. Chandler D. Gatenbee & Ann-Marie Baker & Ryan O. Schenck & Maximilian Strobl & Jeffrey West & Margarida P. Neves & Sara Yakub Hasan & Eszter Lakatos & Pierre Martinez & William C. H. Cross & Marnix Ja, 2022. "Immunosuppressive niche engineering at the onset of human colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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