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A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Author

Listed:
  • Joshua R. Brickner

    (Washington University School of Medicine)

  • Jennifer M. Soll

    (Washington University School of Medicine)

  • Patrick M. Lombardi

    (Johns Hopkins University School of Medicine)

  • Cathrine B. Vågbø

    (Norwegian University of Science and Technology
    PROMEC Core Facility for Proteomics and Metabolomics, NTNU and the Central Norway Regional Health Authority)

  • Miranda C. Mudge

    (Washington University School of Medicine)

  • Clement Oyeniran

    (Washington University School of Medicine)

  • Renana Rabe

    (Norwegian University of Science and Technology)

  • Jessica Jackson

    (St. Louis University School of Medicine)

  • Meagan E. Sullender

    (Washington University School of Medicine)

  • Elyse Blazosky

    (Johns Hopkins University School of Medicine)

  • Andrea K. Byrum

    (Washington University School of Medicine)

  • Yu Zhao

    (Washington University School of Medicine)

  • Mark A. Corbett

    (Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide)

  • Jozef Gécz

    (Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide
    Healthy Mothers and Babies, South Australian Medical Research Institute)

  • Michael Field

    (Genetics of Learning Disability Service, Hunter Genetics)

  • Alessandro Vindigni

    (St. Louis University School of Medicine)

  • Geir Slupphaug

    (Norwegian University of Science and Technology
    PROMEC Core Facility for Proteomics and Metabolomics, NTNU and the Central Norway Regional Health Authority)

  • Cynthia Wolberger

    (Johns Hopkins University School of Medicine)

  • Nima Mosammaparast

    (Washington University School of Medicine)

Abstract

A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

Suggested Citation

  • Joshua R. Brickner & Jennifer M. Soll & Patrick M. Lombardi & Cathrine B. Vågbø & Miranda C. Mudge & Clement Oyeniran & Renana Rabe & Jessica Jackson & Meagan E. Sullender & Elyse Blazosky & Andrea K., 2017. "A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair," Nature, Nature, vol. 551(7680), pages 389-393, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7680:d:10.1038_nature24484
    DOI: 10.1038/nature24484
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