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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Author

Listed:
  • Shabnam Shalapour

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD))

  • Xue-Jia Lin

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    Biomedical Translational Research Institute and The First Affiliated Hospital, Jinan University)

  • Ingmar N. Bastian

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD))

  • John Brain

    (Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University)

  • Alastair D. Burt

    (Faculty of Health and Medical Sciences, University of Adelaide)

  • Alexander A. Aksenov

    (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD))

  • Alison F. Vrbanac

    (University of California San Diego (UCSD))

  • Weihua Li

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD))

  • Andres Perkins

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD))

  • Takaji Matsutani

    (Repertoire Genesis Incorporation)

  • Zhenyu Zhong

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD))

  • Debanjan Dhar

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD))

  • Jose A. Navas-Molina

    (University of California San Diego (UCSD))

  • Jun Xu

    (University of California San Diego (UCSD))

  • Rohit Loomba

    (NAFLD Research Center, University of California San Diego (UCSD))

  • Michael Downes

    (Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies)

  • Ruth T. Yu

    (Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies)

  • Ronald M. Evans

    (Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies)

  • Pieter C. Dorrestein

    (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD)
    Center for Microbiome Innovation, University of California San Diego (UCSD))

  • Rob Knight

    (University of California San Diego (UCSD)
    Center for Microbiome Innovation, University of California San Diego (UCSD))

  • Christopher Benner

    (University of California San Diego (UCSD))

  • Quentin M. Anstee

    (Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    Center for Microbiome Innovation, University of California San Diego (UCSD))

Abstract

IgA+ B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8+ T cells.

Suggested Citation

  • Shabnam Shalapour & Xue-Jia Lin & Ingmar N. Bastian & John Brain & Alastair D. Burt & Alexander A. Aksenov & Alison F. Vrbanac & Weihua Li & Andres Perkins & Takaji Matsutani & Zhenyu Zhong & Debanjan, 2017. "Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity," Nature, Nature, vol. 551(7680), pages 340-345, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7680:d:10.1038_nature24302
    DOI: 10.1038/nature24302
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