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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Author

Listed:
  • Simon Raffel

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    Heidelberg University Hospital)

  • Mattia Falcone

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance)

  • Niclas Kneisel

    (German Cancer Research Center (DKFZ))

  • Jenny Hansson

    (Genome Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Wei Wang

    (German Cancer Research Center (DKFZ))

  • Christoph Lutz

    (Heidelberg University Hospital)

  • Lars Bullinger

    (University Hospital Ulm)

  • Gernot Poschet

    (Centre for Organismal Studies (COS), University of Heidelberg)

  • Yannic Nonnenmacher

    (Technical University Braunschweig
    Luxemburg Centre for Systems Biomedicine, University of Luxemburg)

  • Andrea Barnert

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance)

  • Carsten Bahr

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance)

  • Petra Zeisberger

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance)

  • Adriana Przybylla

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance)

  • Markus Sohn

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance)

  • Martje Tönjes

    (German Cancer Research Center (DKFZ))

  • Ayelet Erez

    (Weizmann Institute of Science)

  • Lital Adler

    (Weizmann Institute of Science)

  • Patrizia Jensen

    (National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ))

  • Claudia Scholl

    (German Cancer Research Center (DKFZ)
    German Cancer Consortium (DKTK), DKFZ)

  • Stefan Fröhling

    (National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
    Section for Personalized Oncology, Heidelberg University Hospital
    German Cancer Consortium (DKTK), DKFZ)

  • Sibylle Cocciardi

    (University Hospital Ulm)

  • Patrick Wuchter

    (Heidelberg University Hospital
    Institute of Transfusion Medicine and Immunology Mannheim, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg-Hessen)

  • Christian Thiede

    (University Hospital Carl Gustav Carus)

  • Anne Flörcken

    (Oncology and Tumor Immunology; Charité-University Medicine Berlin, Campus Virchow Klinikum
    Charité-University Medicine Berlin, Campus Virchow Klinikum)

  • Jörg Westermann

    (Oncology and Tumor Immunology; Charité-University Medicine Berlin, Campus Virchow Klinikum
    Charité-University Medicine Berlin, Campus Virchow Klinikum)

  • Gerhard Ehninger

    (Oncology and Tumor Immunology; Charité-University Medicine Berlin, Campus Virchow Klinikum
    Charité-University Medicine Berlin, Campus Virchow Klinikum)

  • Peter Lichter

    (German Cancer Research Center (DKFZ)
    German Cancer Consortium (DKTK), DKFZ)

  • Karsten Hiller

    (Technical University Braunschweig
    Luxemburg Centre for Systems Biomedicine, University of Luxemburg)

  • Rüdiger Hell

    (Centre for Organismal Studies (COS), University of Heidelberg)

  • Carl Herrmann

    (German Cancer Research Center (DKFZ)
    Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg)

  • Anthony D. Ho

    (Heidelberg University Hospital)

  • Jeroen Krijgsveld

    (Genome Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Bernhard Radlwimmer

    (German Cancer Research Center (DKFZ)
    German Cancer Consortium (DKTK), DKFZ)

  • Andreas Trumpp

    (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
    German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
    German Cancer Consortium (DKTK), DKFZ)

Abstract

The mechanistic basis for the role of the metabolic enzyme BCAA transaminase 1 (BCAT1) in acute myeloid leukaemias.

Suggested Citation

  • Simon Raffel & Mattia Falcone & Niclas Kneisel & Jenny Hansson & Wei Wang & Christoph Lutz & Lars Bullinger & Gernot Poschet & Yannic Nonnenmacher & Andrea Barnert & Carsten Bahr & Petra Zeisberger & , 2017. "BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation," Nature, Nature, vol. 551(7680), pages 384-388, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7680:d:10.1038_nature24294
    DOI: 10.1038/nature24294
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    Cited by:

    1. Kevin M. Rattigan & Zuzana Brabcova & Daniele Sarnello & Martha M. Zarou & Kiron Roy & Ryan Kwan & Lucie Beauchamp & Amy Dawson & Angela Ianniciello & Ahmed Khalaf & Eric R. Kalkman & Mary T. Scott & , 2023. "Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Lina Liu & Ana Vujovic & Nandan P. Deshpande & Shashank Sathe & Govardhan Anande & He Tian Tony Chen & Joshua Xu & Mark D. Minden & Gene W. Yeo & Ashwin Unnikrishnan & Kristin J. Hope & Yu Lu, 2022. "The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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