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Kctd13 deletion reduces synaptic transmission via increased RhoA

Author

Listed:
  • Christine Ochoa Escamilla

    (University of Texas Southwestern Medical Center)

  • Irina Filonova

    (University of Texas Southwestern Medical Center
    Okinawa Institute of Science and Technology Graduate University)

  • Angela K. Walker

    (University of Texas Southwestern Medical Center)

  • Zhong X. Xuan

    (University of Texas Southwestern Medical Center)

  • Roopashri Holehonnur

    (University of Texas Southwestern Medical Center)

  • Felipe Espinosa

    (University of Texas Southwestern Medical Center)

  • Shunan Liu

    (University of Texas Southwestern Medical Center)

  • Summer B. Thyme

    (Harvard University)

  • Isabel A. López-García

    (University of Texas Southwestern Medical Center)

  • Dorian B. Mendoza

    (University of Texas Southwestern Medical Center)

  • Noriyoshi Usui

    (University of Texas Southwestern Medical Center
    University of Fukui
    Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui)

  • Jacob Ellegood

    (Mouse Imaging Centre (MICe), Hospital for Sick Children)

  • Amelia J. Eisch

    (University of Texas Southwestern Medical Center
    University of Pennsylvania Perelman School of Medicine
    The Children’s Hospital of Philadelphia)

  • Genevieve Konopka

    (University of Texas Southwestern Medical Center)

  • Jason P. Lerch

    (Mouse Imaging Centre (MICe), Hospital for Sick Children
    University of Toronto)

  • Alexander F. Schier

    (Harvard University
    Center for Brain Science, Harvard University
    Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute)

  • Haley E. Speed

    (University of Texas Southwestern Medical Center)

  • Craig M. Powell

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13.

Suggested Citation

  • Christine Ochoa Escamilla & Irina Filonova & Angela K. Walker & Zhong X. Xuan & Roopashri Holehonnur & Felipe Espinosa & Shunan Liu & Summer B. Thyme & Isabel A. López-García & Dorian B. Mendoza & Nor, 2017. "Kctd13 deletion reduces synaptic transmission via increased RhoA," Nature, Nature, vol. 551(7679), pages 227-231, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7679:d:10.1038_nature24470
    DOI: 10.1038/nature24470
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    Cited by:

    1. Elaine T. Lim & Yingleong Chan & Pepper Dawes & Xiaoge Guo & Serkan Erdin & Derek J. C. Tai & Songlei Liu & Julia M. Reichert & Mannix J. Burns & Ying Kai Chan & Jessica J. Chiang & Katharina Meyer & , 2022. "Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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