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The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

Author

Listed:
  • Modi Safra

    (Weizmann Institute of Science)

  • Aldema Sas-Chen

    (Weizmann Institute of Science)

  • Ronit Nir

    (Weizmann Institute of Science)

  • Roni Winkler

    (Weizmann Institute of Science)

  • Aharon Nachshon

    (Weizmann Institute of Science)

  • Dan Bar-Yaacov

    (Weizmann Institute of Science)

  • Matthias Erlacher

    (Biocenter Innsbruck, Medical University of Innsbruck)

  • Walter Rossmanith

    (Center for Anatomy and Cell Biology, Medical University of Vienna)

  • Noam Stern-Ginossar

    (Weizmann Institute of Science)

  • Schraga Schwartz

    (Weizmann Institute of Science)

Abstract

Transcriptome-wide mapping of N1-methyladenosine (m1A) at single-nucleotide resolution reveals m1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.

Suggested Citation

  • Modi Safra & Aldema Sas-Chen & Ronit Nir & Roni Winkler & Aharon Nachshon & Dan Bar-Yaacov & Matthias Erlacher & Walter Rossmanith & Noam Stern-Ginossar & Schraga Schwartz, 2017. "The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution," Nature, Nature, vol. 551(7679), pages 251-255, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7679:d:10.1038_nature24456
    DOI: 10.1038/nature24456
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    Cited by:

    1. Katja Hartstock & Nadine A. Kueck & Petr Spacek & Anna Ovcharenko & Sabine Hüwel & Nicolas V. Cornelissen & Amarnath Bollu & Christoph Dieterich & Andrea Rentmeister, 2023. "MePMe-seq: antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Belinda Baquero-Pérez & Ivaylo D. Yonchev & Anna Delgado-Tejedor & Rebeca Medina & Mireia Puig-Torrents & Ian Sudbery & Oguzhan Begik & Stuart A. Wilson & Eva Maria Novoa & Juana Díez, 2024. "N6-methyladenosine modification is not a general trait of viral RNA genomes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Ziyuan Wang & Yinshan Fang & Ziyang Liu & Ning Hao & Hao Helen Zhang & Xiaoxiao Sun & Jianwen Que & Hongxu Ding, 2024. "Adapting nanopore sequencing basecalling models for modification detection via incremental learning and anomaly detection," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Jianheng Liu & Tao Huang & Jing Yao & Tianxuan Zhao & Yusen Zhang & Rui Zhang, 2023. "Epitranscriptomic subtyping, visualization, and denoising by global motif visualization," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Hongna Zuo & Aiwei Wu & Mingwei Wang & Liquan Hong & Hu Wang, 2024. "tRNA m1A modification regulate HSC maintenance and self-renewal via mTORC1 signaling," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Zhangli Su & Ida Monshaugen & Briana Wilson & Fengbin Wang & Arne Klungland & Rune Ougland & Anindya Dutta, 2022. "TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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