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Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

Author

Listed:
  • Ziqing Liu

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Li Wang

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Joshua D. Welch

    (University of North Carolina at Chapel Hill)

  • Hong Ma

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Yang Zhou

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Haley Ruth Vaseghi

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Shuo Yu

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Joseph Blake Wall

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Sahar Alimohamadi

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Michael Zheng

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Chaoying Yin

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Weining Shen

    (University of California at Irvine)

  • Jan F. Prins

    (University of North Carolina at Chapel Hill)

  • Jiandong Liu

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Li Qian

    (McAllister Heart Institute, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

Abstract

Single-cell transcriptomics analyses of cell intermediates during the reprogramming from fibroblast to cardiomyocyte were used to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in this process.

Suggested Citation

  • Ziqing Liu & Li Wang & Joshua D. Welch & Hong Ma & Yang Zhou & Haley Ruth Vaseghi & Shuo Yu & Joseph Blake Wall & Sahar Alimohamadi & Michael Zheng & Chaoying Yin & Weining Shen & Jan F. Prins & Jiand, 2017. "Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte," Nature, Nature, vol. 551(7678), pages 100-104, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24454
    DOI: 10.1038/nature24454
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    Cited by:

    1. Hongyu Liu & Ran Duan & Xiaoyu He & Jincu Qi & Tianming Xing & Yahan Wu & Liping Zhou & Lingling Wang & Yujing Shao & Fulei Zhang & Huixing Zhou & Xingdong Gu & Bowen Lin & Yuanyuan Liu & Yan Wang & Y, 2023. "Endothelial deletion of PTBP1 disrupts ventricular chamber development," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Maria A. Missinato & Sean Murphy & Michaela Lynott & Michael S. Yu & Anaïs Kervadec & Yu-Ling Chang & Suraj Kannan & Mafalda Loreti & Christopher Lee & Prashila Amatya & Hiroshi Tanaka & Chun-Teng Hua, 2023. "Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Urban Lendahl & Lars Muhl & Christer Betsholtz, 2022. "Identification, discrimination and heterogeneity of fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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