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IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Author

Listed:
  • Martina Molgora

    (Humanitas Clinical and Research Center)

  • Eduardo Bonavita

    (Humanitas Clinical and Research Center
    The University of Manchester)

  • Andrea Ponzetta

    (Humanitas Clinical and Research Center)

  • Federica Riva

    (Faculty of Veterinary Medicine, University of Milan)

  • Marialuisa Barbagallo

    (Humanitas Clinical and Research Center)

  • Sébastien Jaillon

    (Humanitas Clinical and Research Center
    Humanitas University)

  • Branka Popović

    (Faculty of Medicine, University of Rijeka)

  • Giovanni Bernardini

    (Università di Roma “La Sapienza”
    IRCCS Neuromed)

  • Elena Magrini

    (Humanitas Clinical and Research Center)

  • Francesca Gianni

    (Humanitas Clinical and Research Center)

  • Santiago Zelenay

    (Cancer Research UK Manchester Institute, The University of Manchester)

  • Stipan Jonjić

    (Faculty of Medicine, University of Rijeka)

  • Angela Santoni

    (Università di Roma “La Sapienza”
    IRCCS Neuromed)

  • Cecilia Garlanda

    (Humanitas Clinical and Research Center
    Humanitas University)

  • Alberto Mantovani

    (Humanitas Clinical and Research Center
    Humanitas University
    The William Harvey Research Institute, Queen Mary University of London)

Abstract

Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.

Suggested Citation

  • Martina Molgora & Eduardo Bonavita & Andrea Ponzetta & Federica Riva & Marialuisa Barbagallo & Sébastien Jaillon & Branka Popović & Giovanni Bernardini & Elena Magrini & Francesca Gianni & Santiago Ze, 2017. "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity," Nature, Nature, vol. 551(7678), pages 110-114, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24293
    DOI: 10.1038/nature24293
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    Cited by:

    1. Federica Portale & Roberta Carriero & Marta Iovino & Paolo Kunderfranco & Marta Pandini & Giulia Marelli & Nicolò Morina & Massimo Lazzeri & Paolo Casale & Piergiuseppe Colombo & Gabriele Simone & Chi, 2024. "C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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