IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v551y2017i7678d10.1038_nature24283.html
   My bibliography  Save this article

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

Author

Listed:
  • Song Zhang

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Motoki Takaku

    (Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park)

  • Liyun Zou

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Ai-di Gu

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Wei-chun Chou

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Ge Zhang

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    Dalian Medical University)

  • Bing Wu

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Qing Kong

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Seddon Y. Thomas

    (Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park)

  • Jonathan S. Serody

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Xian Chen

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Xiaojiang Xu

    (Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park)

  • Paul A. Wade

    (Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park)

  • Donald N. Cook

    (Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park)

  • Jenny P. Y. Ting

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Yisong Y. Wan

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

Abstract

TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.

Suggested Citation

  • Song Zhang & Motoki Takaku & Liyun Zou & Ai-di Gu & Wei-chun Chou & Ge Zhang & Bing Wu & Qing Kong & Seddon Y. Thomas & Jonathan S. Serody & Xian Chen & Xiaojiang Xu & Paul A. Wade & Donald N. Cook & , 2017. "Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation," Nature, Nature, vol. 551(7678), pages 105-109, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24283
    DOI: 10.1038/nature24283
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24283
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature24283?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24283. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.