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Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus

Author

Listed:
  • Ming Jiang

    (Columbia University Medical Center)

  • Haiyan Li

    (Columbia University Medical Center)

  • Yongchun Zhang

    (Columbia University Medical Center)

  • Ying Yang

    (Columbia University Medical Center)

  • Rong Lu

    (Columbia University Medical Center)

  • Kuancan Liu

    (Columbia University Medical Center
    Institute for Laboratory Medicine, Fuzhou General Hospital)

  • Sijie Lin

    (Columbia University Medical Center
    Institute for Laboratory Medicine, Fuzhou General Hospital)

  • Xiaopeng Lan

    (Institute for Laboratory Medicine, Fuzhou General Hospital)

  • Haikun Wang

    (CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Han Wu

    (Ascendas Genomics Inc.)

  • Jian Zhu

    (School of Medicine and Dentistry, University of Rochester)

  • Zhongren Zhou

    (School of Medicine and Dentistry, University of Rochester)

  • Jianming Xu

    (Baylor College of Medicine
    Institute for Cancer Medicine, School of Basic Medical Sciences, Southwest Medical University)

  • Dong-Kee Lee

    (Baylor College of Medicine)

  • Lanjing Zhang

    (University Medical Center of Princeton at Plainsboro
    Rutgers University)

  • Yuan-Cho Lee

    (Columbia University Medical Center)

  • Jingsong Yuan

    (Columbia University Medical Center)

  • Julian A. Abrams

    (Columbia University Medical Center)

  • Timothy C. Wang

    (Columbia University Medical Center)

  • Antonia R. Sepulveda

    (Columbia University Medical Center)

  • Qi Wu

    (Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University)

  • Huaiyong Chen

    (Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University)

  • Xin Sun

    (Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University)

  • Junjun She

    (First Affiliated Hospital of Medical College, Xi’an Jiaotong University)

  • Xiaoxin Chen

    (Biomedical/Biotechnology Research Institute, North Carolina Central University)

  • Jianwen Que

    (Columbia University Medical Center)

Abstract

Barrett’s oesophagus—a metaplasia that can be induced by persistent acid reflux, and predisposes patients to oesophageal cancer—arises from a population of basal cells at the gastro-oesophageal junction.

Suggested Citation

  • Ming Jiang & Haiyan Li & Yongchun Zhang & Ying Yang & Rong Lu & Kuancan Liu & Sijie Lin & Xiaopeng Lan & Haikun Wang & Han Wu & Jian Zhu & Zhongren Zhou & Jianming Xu & Dong-Kee Lee & Lanjing Zhang & , 2017. "Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus," Nature, Nature, vol. 550(7677), pages 529-533, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7677:d:10.1038_nature24269
    DOI: 10.1038/nature24269
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    Cited by:

    1. Naveen Kumar & Pon Ganish Prakash & Christian Wentland & Shilpa Mary Kurian & Gaurav Jethva & Volker Brinkmann & Hans-Joachim Mollenkopf & Tobias Krammer & Christophe Toussaint & Antoine-Emmanuel Sali, 2024. "Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Takeshi Katsuda & Jonathan H. Sussman & Kenji Ito & Andrew Katznelson & Salina Yuan & Naomi Takenaka & Jinyang Li & Allyson J. Merrell & Hector Cure & Qinglan Li & Reyaz Ur Rasool & Irfan A. Asangani , 2024. "Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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