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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

Author

Listed:
  • Thiet M. Vu

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Ayako-Nakamura Ishizu

    (Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore)

  • Juat Chin Foo

    (Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Xiu Ru Toh

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Fangyu Zhang

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Ding Ming Whee

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Federico Torta

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Amaury Cazenave-Gassiot

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Takayoshi Matsumura

    (Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore)

  • Sangho Kim

    (National University of Singapore
    Biomedical Institute for Global Health Research and Technology, National University of Singapore
    NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore)

  • Sue-Anne E. S. Toh

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Toshio Suda

    (Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore)

  • David L. Silver

    (Signature Research Program in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School)

  • Markus R. Wenk

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Long N. Nguyen

    (Yong Loo Lin School of Medicine, National University of Singapore)

Abstract

Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

Suggested Citation

  • Thiet M. Vu & Ayako-Nakamura Ishizu & Juat Chin Foo & Xiu Ru Toh & Fangyu Zhang & Ding Ming Whee & Federico Torta & Amaury Cazenave-Gassiot & Takayoshi Matsumura & Sangho Kim & Sue-Anne E. S. Toh & To, 2017. "Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets," Nature, Nature, vol. 550(7677), pages 524-528, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7677:d:10.1038_nature24053
    DOI: 10.1038/nature24053
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    Cited by:

    1. Amin Polzin & Lisa Dannenberg & Marcel Benkhoff & Maike Barcik & Carolin Helten & Philipp Mourikis & Samantha Ahlbrecht & Laura Wildeis & Justus Ziese & Dorothee Zikeli & Daniel Metzen & Hao Hu & Leon, 2023. "Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Chi Nguyen & Hsiang-Ting Lei & Louis Tung Faat Lai & Marc J. Gallenito & Xuelang Mu & Doreen Matthies & Tamir Gonen, 2023. "Lipid flipping in the omega-3 fatty-acid transporter," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Elisabeth Lambert & Ahmad Reza Mehdipour & Alexander Schmidt & Gerhard Hummer & Camilo Perez, 2022. "Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Nadine Thomas & Nathalie H. Schröder & Melissa K. Nowak & Philipp Wollnitzke & Shahrooz Ghaderi & Karin Wnuck Lipinski & Annalena Wille & Jennifer Deister-Jonas & Jens Vogt & Markus H. Gräler & Lisa D, 2023. "Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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