IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v550y2017i7677d10.1038_nature24053.html
   My bibliography  Save this article

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

Author

Listed:
  • Thiet M. Vu

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Ayako-Nakamura Ishizu

    (Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore)

  • Juat Chin Foo

    (Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Xiu Ru Toh

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Fangyu Zhang

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Ding Ming Whee

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Federico Torta

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Amaury Cazenave-Gassiot

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Takayoshi Matsumura

    (Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore)

  • Sangho Kim

    (National University of Singapore
    Biomedical Institute for Global Health Research and Technology, National University of Singapore
    NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore)

  • Sue-Anne E. S. Toh

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Toshio Suda

    (Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore)

  • David L. Silver

    (Signature Research Program in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School)

  • Markus R. Wenk

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore)

  • Long N. Nguyen

    (Yong Loo Lin School of Medicine, National University of Singapore)

Abstract

Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

Suggested Citation

  • Thiet M. Vu & Ayako-Nakamura Ishizu & Juat Chin Foo & Xiu Ru Toh & Fangyu Zhang & Ding Ming Whee & Federico Torta & Amaury Cazenave-Gassiot & Takayoshi Matsumura & Sangho Kim & Sue-Anne E. S. Toh & To, 2017. "Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets," Nature, Nature, vol. 550(7677), pages 524-528, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7677:d:10.1038_nature24053
    DOI: 10.1038/nature24053
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24053
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature24053?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Amin Polzin & Lisa Dannenberg & Marcel Benkhoff & Maike Barcik & Carolin Helten & Philipp Mourikis & Samantha Ahlbrecht & Laura Wildeis & Justus Ziese & Dorothee Zikeli & Daniel Metzen & Hao Hu & Leon, 2023. "Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Elisabeth Lambert & Ahmad Reza Mehdipour & Alexander Schmidt & Gerhard Hummer & Camilo Perez, 2022. "Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Nadine Thomas & Nathalie H. Schröder & Melissa K. Nowak & Philipp Wollnitzke & Shahrooz Ghaderi & Karin Wnuck Lipinski & Annalena Wille & Jennifer Deister-Jonas & Jens Vogt & Markus H. Gräler & Lisa D, 2023. "Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Chi Nguyen & Hsiang-Ting Lei & Louis Tung Faat Lai & Marc J. Gallenito & Xuelang Mu & Doreen Matthies & Tamir Gonen, 2023. "Lipid flipping in the omega-3 fatty-acid transporter," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:550:y:2017:i:7677:d:10.1038_nature24053. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.