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USP7 small-molecule inhibitors interfere with ubiquitin binding

Author

Listed:
  • Lorna Kategaya

    (Genentech
    Genentech)

  • Paola Di Lello

    (Genentech)

  • Lionel Rougé

    (Genentech)

  • Richard Pastor

    (Genentech)

  • Kevin R. Clark

    (Genentech)

  • Jason Drummond

    (Genentech)

  • Tracy Kleinheinz

    (Genentech)

  • Eva Lin

    (Genentech)

  • John-Paul Upton

    (Genentech
    Genentech)

  • Sumit Prakash

    (Genentech
    Genentech)

  • Johanna Heideker

    (Genentech
    Genentech)

  • Mark McCleland

    (Genentech
    Genentech)

  • Maria Stella Ritorto

    (MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee)

  • Dario R. Alessi

    (MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee)

  • Matthias Trost

    (Institute for Cell and Molecular Biosciences, Newcastle University)

  • Travis W. Bainbridge

    (Genentech)

  • Michael C. M. Kwok

    (Genentech)

  • Taylur P. Ma

    (Proteomics, and Lipidomics, Genentech)

  • Zachary Stiffler

    (Boston Biochem)

  • Bradley Brasher

    (Boston Biochem)

  • Yinyan Tang

    (University of California, San Francisco)

  • Priyadarshini Jaishankar

    (University of California, San Francisco)

  • Brian R. Hearn

    (University of California, San Francisco)

  • Adam R. Renslo

    (University of California, San Francisco)

  • Michelle R. Arkin

    (University of California, San Francisco)

  • Frederick Cohen

    (Genentech)

  • Kebing Yu

    (Proteomics, and Lipidomics, Genentech)

  • Frank Peale

    (Genentech)

  • Florian Gnad

    (Genentech)

  • Matthew T. Chang

    (Genentech)

  • Christiaan Klijn

    (Genentech)

  • Elizabeth Blackwood

    (Genentech)

  • Scott E. Martin

    (Genentech)

  • William F. Forrest

    (Genentech)

  • James A. Ernst

    (Genentech)

  • Chudi Ndubaku

    (Genentech)

  • Xiaojing Wang

    (Genentech)

  • Maureen H. Beresini

    (Genentech)

  • Vickie Tsui

    (Genentech)

  • Carsten Schwerdtfeger

    (Boston Biochem)

  • Robert A. Blake

    (Genentech)

  • Jeremy Murray

    (Genentech)

  • Till Maurer

    (Genentech)

  • Ingrid E. Wertz

    (Genentech
    Genentech)

Abstract

The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

Suggested Citation

  • Lorna Kategaya & Paola Di Lello & Lionel Rougé & Richard Pastor & Kevin R. Clark & Jason Drummond & Tracy Kleinheinz & Eva Lin & John-Paul Upton & Sumit Prakash & Johanna Heideker & Mark McCleland & M, 2017. "USP7 small-molecule inhibitors interfere with ubiquitin binding," Nature, Nature, vol. 550(7677), pages 534-538, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7677:d:10.1038_nature24006
    DOI: 10.1038/nature24006
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    Citations

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    Cited by:

    1. Fredrik Trulsson & Vyacheslav Akimov & Mihaela Robu & Nila Overbeek & David Aureliano Pérez Berrocal & Rashmi G. Shah & Jürgen Cox & Girish M. Shah & Blagoy Blagoev & Alfred C. O. Vertegaal, 2022. "Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Teodora Manea & Jessica Kristine Nelson & Cristina Maria Garrone & Karin Hansson & Ian Evans & Axel Behrens & Rocio Sancho, 2023. "USP7 controls NGN3 stability and pancreatic endocrine lineage development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Zachary T. Spencer & Victoria H. Ng & Hassina Benchabane & Ghalia Saad Siddiqui & Deepesh Duwadi & Ben Maines & Jamal M. Bryant & Anna Schwarzkopf & Kai Yuan & Sara N. Kassel & Anant Mishra & Ashley P, 2023. "The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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