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DNA sequencing at 40: past, present and future

Author

Listed:
  • Jay Shendure

    (University of Washington
    Howard Hughes Medical Institute)

  • Shankar Balasubramanian

    (University of Cambridge
    Cancer Research UK Cambridge Institute, University of Cambridge)

  • George M. Church

    (Harvard Medical School)

  • Walter Gilbert

    (Harvard University)

  • Jane Rogers

    (International Wheat Genome Sequencing Consortium)

  • Jeffery A. Schloss

    (National Human Genome Research Institute, National Institutes of Health)

  • Robert H. Waterston

    (University of Washington)

Abstract

This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has been extensively and creatively repurposed, including as a ‘counter’ for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA sequencing will be on a par with that of the microscope.

Suggested Citation

  • Jay Shendure & Shankar Balasubramanian & George M. Church & Walter Gilbert & Jane Rogers & Jeffery A. Schloss & Robert H. Waterston, 2017. "DNA sequencing at 40: past, present and future," Nature, Nature, vol. 550(7676), pages 345-353, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7676:d:10.1038_nature24286
    DOI: 10.1038/nature24286
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    Citations

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    Cited by:

    1. Christoph Ziegenhain & Rickard Sandberg, 2021. "BAMboozle removes genetic variation from human sequence data for open data sharing," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Hinako Kawabe & Christopher A. Thomas & Shuichi Hoshika & Myong-Jung Kim & Myong-Sang Kim & Logan Miessner & Nicholas Kaplan & Jonathan M. Craig & Jens H. Gundlach & Andrew H. Laszlo & Steven A. Benne, 2023. "Enzymatic synthesis and nanopore sequencing of 12-letter supernumerary DNA," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Hannes Rothe & Katharina Barbara Lauer & Callum Talbot-Cooper & Daniel Juan Sivizaca Conde, 2023. "Digital entrepreneurship from cellular data: How omics afford the emergence of a new wave of digital ventures in health," Electronic Markets, Springer;IIM University of St. Gallen, vol. 33(1), pages 1-17, December.
    4. Tony Z. Jia & Yutetsu Kuruma, 2019. "Recent Advances in Origins of Life Research by Biophysicists in Japan," Challenges, MDPI, vol. 10(1), pages 1-21, April.
    5. Susanne Theuerl & Christiane Herrmann & Monika Heiermann & Philipp Grundmann & Niels Landwehr & Ulrich Kreidenweis & Annette Prochnow, 2019. "The Future Agricultural Biogas Plant in Germany: A Vision," Energies, MDPI, vol. 12(3), pages 1-32, January.
    6. Sina Majidian & Mohammad Hossein Kahaei & Dick de Ridder, 2020. "Minimum error correction-based haplotype assembly: Considerations for long read data," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-12, June.
    7. Susanne Theuerl & Johanna Klang & Annette Prochnow, 2019. "Process Disturbances in Agricultural Biogas Production—Causes, Mechanisms and Effects on the Biogas Microbiome: A Review," Energies, MDPI, vol. 12(3), pages 1-20, January.

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