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Radically truncated MeCP2 rescues Rett syndrome-like neurological defects

Author

Listed:
  • Rebekah Tillotson

    (The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King’s Buildings, Max Born Crescent)

  • Jim Selfridge

    (The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King’s Buildings, Max Born Crescent)

  • Martha V. Koerner

    (The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King’s Buildings, Max Born Crescent)

  • Kamal K. E. Gadalla

    (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow
    Faculty of Medicine, Tanta University)

  • Jacky Guy

    (The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King’s Buildings, Max Born Crescent)

  • Dina De Sousa

    (The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King’s Buildings, Max Born Crescent)

  • Ralph D. Hector

    (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Stuart R. Cobb

    (Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Adrian Bird

    (The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King’s Buildings, Max Born Crescent)

Abstract

Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.

Suggested Citation

  • Rebekah Tillotson & Jim Selfridge & Martha V. Koerner & Kamal K. E. Gadalla & Jacky Guy & Dina De Sousa & Ralph D. Hector & Stuart R. Cobb & Adrian Bird, 2017. "Radically truncated MeCP2 rescues Rett syndrome-like neurological defects," Nature, Nature, vol. 550(7676), pages 398-401, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7676:d:10.1038_nature24058
    DOI: 10.1038/nature24058
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    Cited by:

    1. Jing Zhang & Huili Li & Lee A. Niswander, 2024. "m5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Raphaël Pantier & Megan Brown & Sicheng Han & Katie Paton & Stephen Meek & Thomas Montavon & Nicholas Shukeir & Toni McHugh & David A. Kelly & Tino Hochepied & Claude Libert & Thomas Jenuwein & Tom Bu, 2024. "MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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