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Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

Author

Listed:
  • Marscha Hirschi

    (Duke University School of Medicine)

  • Mark A. Herzik Jr

    (The Scripps Research Institute)

  • Jinhong Wie

    (University of Pennsylvania)

  • Yang Suo

    (Duke University School of Medicine)

  • William F. Borschel

    (Duke University School of Medicine)

  • Dejian Ren

    (University of Pennsylvania)

  • Gabriel C. Lander

    (The Scripps Research Institute)

  • Seok-Yong Lee

    (Duke University School of Medicine)

Abstract

A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel.

Suggested Citation

  • Marscha Hirschi & Mark A. Herzik Jr & Jinhong Wie & Yang Suo & William F. Borschel & Dejian Ren & Gabriel C. Lander & Seok-Yong Lee, 2017. "Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3," Nature, Nature, vol. 550(7676), pages 411-414, October.
  • Handle: RePEc:nat:nature:v:550:y:2017:i:7676:d:10.1038_nature24055
    DOI: 10.1038/nature24055
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