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Cytoplasmic chromatin triggers inflammation in senescence and cancer

Author

Listed:
  • Zhixun Dou

    (Perelman School of Medicine, University of Pennsylvania)

  • Kanad Ghosh

    (Perelman School of Medicine, University of Pennsylvania)

  • Maria Grazia Vizioli

    (Beatson Institute for Cancer Research
    Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Jiajun Zhu

    (Perelman School of Medicine, University of Pennsylvania)

  • Payel Sen

    (Perelman School of Medicine, University of Pennsylvania)

  • Kirk J. Wangensteen

    (University of Pennsylvania)

  • Johayra Simithy

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Yemin Lan

    (Perelman School of Medicine, University of Pennsylvania)

  • Yanping Lin

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Zhuo Zhou

    (Biodynamic Optical Imaging Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University)

  • Brian C. Capell

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Caiyue Xu

    (Perelman School of Medicine, University of Pennsylvania)

  • Mingang Xu

    (Perelman School of Medicine, University of Pennsylvania)

  • Julia E. Kieckhaefer

    (University of Pennsylvania
    Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania)

  • Tianying Jiang

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Michal Shoshkes-Carmel

    (University of Pennsylvania
    Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania)

  • K. M. Ahasan Al Tanim

    (Perelman School of Medicine, University of Pennsylvania)

  • Glen N. Barber

    (University of Miami Miller School of Medicine)

  • John T. Seykora

    (Perelman School of Medicine, University of Pennsylvania)

  • Sarah E. Millar

    (Perelman School of Medicine, University of Pennsylvania)

  • Klaus H. Kaestner

    (University of Pennsylvania
    Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania)

  • Benjamin A. Garcia

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania
    Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania)

  • Peter D. Adams

    (Beatson Institute for Cancer Research
    Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
    Sanford Burnham Prebys Medical Discovery Institute)

  • Shelley L. Berger

    (Perelman School of Medicine, University of Pennsylvania
    University of Pennsylvania
    Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania
    School of Arts and Sciences, University of Pennsylvania)

Abstract

Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

Suggested Citation

  • Zhixun Dou & Kanad Ghosh & Maria Grazia Vizioli & Jiajun Zhu & Payel Sen & Kirk J. Wangensteen & Johayra Simithy & Yemin Lan & Yanping Lin & Zhuo Zhou & Brian C. Capell & Caiyue Xu & Mingang Xu & Juli, 2017. "Cytoplasmic chromatin triggers inflammation in senescence and cancer," Nature, Nature, vol. 550(7676), pages 402-406, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7676:d:10.1038_nature24050
    DOI: 10.1038/nature24050
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