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TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

Author

Listed:
  • Manoël Prouteau

    (University of Geneva
    Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva)

  • Ambroise Desfosses

    (School of Biological Sciences, University of Auckland)

  • Christian Sieben

    (Institute of Physics, Laboratory of Experimental Biophysics, École Polytechnique Fédérale de Lausanne (EPFL)
    Swiss National Centre for Competence in Research (NCCR) in Chemical Biology. University of Geneva, Sciences II, room 3-308)

  • Clélia Bourgoint

    (University of Geneva
    Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva)

  • Nour Lydia Mozaffari

    (University of Geneva
    Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
    Institute of Physics, Laboratory of Experimental Biophysics, École Polytechnique Fédérale de Lausanne (EPFL)
    Swiss National Centre for Competence in Research (NCCR) in Chemical Biology. University of Geneva, Sciences II, room 3-308)

  • Davide Demurtas

    (Interdisciplinary Centre for Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL))

  • Alok K. Mitra

    (School of Biological Sciences, University of Auckland)

  • Paul Guichard

    (University of Geneva)

  • Suliana Manley

    (Institute of Physics, Laboratory of Experimental Biophysics, École Polytechnique Fédérale de Lausanne (EPFL)
    Swiss National Centre for Competence in Research (NCCR) in Chemical Biology. University of Geneva, Sciences II, room 3-308)

  • Robbie Loewith

    (University of Geneva
    Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
    Swiss National Centre for Competence in Research (NCCR) in Chemical Biology. University of Geneva, Sciences II, room 3-308)

Abstract

In budding yeast, glucose withdrawal, via the Rag GTPases, leads to TORC1 inhibition through its re-organization into a giant, vacuole-associated helix named a TOROID (TORC1 organized in inhibited domain).

Suggested Citation

  • Manoël Prouteau & Ambroise Desfosses & Christian Sieben & Clélia Bourgoint & Nour Lydia Mozaffari & Davide Demurtas & Alok K. Mitra & Paul Guichard & Suliana Manley & Robbie Loewith, 2017. "TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity," Nature, Nature, vol. 550(7675), pages 265-269, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7675:d:10.1038_nature24021
    DOI: 10.1038/nature24021
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