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CG dinucleotide suppression enables antiviral defence targeting non-self RNA

Author

Listed:
  • Matthew A. Takata

    (Laboratory of Retrovirology, The Rockefeller University)

  • Daniel Gonçalves-Carneiro

    (Laboratory of Retrovirology, The Rockefeller University)

  • Trinity M. Zang

    (Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

  • Steven J. Soll

    (Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

  • Ashley York

    (Laboratory of Retrovirology, The Rockefeller University)

  • Daniel Blanco-Melo

    (Laboratory of Retrovirology, The Rockefeller University)

  • Paul D. Bieniasz

    (Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

Abstract

Vertebrate genomes contain fewer CG dinucleotides than would be expected by chance, and this pattern is mimicked by many viruses; HIV-1 derivatives mutated to contain more CG dinucleotides are targeted by the human antiviral protein ZAP, suggesting that CG suppression has evolved in viruses to evade recognition.

Suggested Citation

  • Matthew A. Takata & Daniel Gonçalves-Carneiro & Trinity M. Zang & Steven J. Soll & Ashley York & Daniel Blanco-Melo & Paul D. Bieniasz, 2017. "CG dinucleotide suppression enables antiviral defence targeting non-self RNA," Nature, Nature, vol. 550(7674), pages 124-127, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7674:d:10.1038_nature24039
    DOI: 10.1038/nature24039
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    Cited by:

    1. Kate Bredbenner & Sanford M Simon, 2019. "Video abstracts and plain language summaries are more effective than graphical abstracts and published abstracts," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-19, November.

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