IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v550y2017i7674d10.1038_nature24027.html
   My bibliography  Save this article

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics

Author

Listed:
  • Ulrich Elling

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Reiner A. Wimmer

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Andreas Leibbrandt

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Thomas Burkard

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Georg Michlits

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Alexandra Leopoldi

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Thomas Micheler

    (Vienna Biocenter Core Facilities, Vienna Biocenter (VBC))

  • Dana Abdeen

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Sergei Zhuk

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Irene M. Aspalter

    (MRC Laboratory for Molecular Cell Biology and Institute for the Physics of Living Systems, University College London)

  • Cornelia Handl

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Julia Liebergesell

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Maria Hubmann

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Anna-Maria Husa

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Manuela Kinzer

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Nicole Schuller

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Ellen Wetzel

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Nina van de Loo

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Jorge Arturo Zepeda Martinez

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • David Estoppey

    (Novartis Institutes for BioMedical Research)

  • Ralph Riedl

    (Novartis Institutes for BioMedical Research)

  • Fengtang Yang

    (Wellcome Trust Sanger Institute)

  • Beiyuan Fu

    (Wellcome Trust Sanger Institute)

  • Thomas Dechat

    (Max F. Perutz Laboratories, Medical University of Vienna)

  • Zoltán Ivics

    (Paul Ehrlich Institut)

  • Chukwuma A. Agu

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Oliver Bell

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

  • Dieter Blaas

    (Max F. Perutz Laboratories, Medical University of Vienna)

  • Holger Gerhardt

    (Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
    German Center for Cardiovascular Research
    Berlin Institute of Health)

  • Dominic Hoepfner

    (Novartis Institutes for BioMedical Research)

  • Alexander Stark

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Josef M. Penninger

    (Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC))

Abstract

The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.

Suggested Citation

  • Ulrich Elling & Reiner A. Wimmer & Andreas Leibbrandt & Thomas Burkard & Georg Michlits & Alexandra Leopoldi & Thomas Micheler & Dana Abdeen & Sergei Zhuk & Irene M. Aspalter & Cornelia Handl & Julia , 2017. "A reversible haploid mouse embryonic stem cell biobank resource for functional genomics," Nature, Nature, vol. 550(7674), pages 114-118, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7674:d:10.1038_nature24027
    DOI: 10.1038/nature24027
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24027
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature24027?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Daniel Bsteh & Hagar F. Moussa & Georg Michlits & Ramesh Yelagandula & Jingkui Wang & Ulrich Elling & Oliver Bell, 2023. "Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Vanessa Monteil & Hyesoo Kwon & Lijo John & Cristiano Salata & Gustav Jonsson & Sabine U. Vorrink & Sofia Appelberg & Sonia Youhanna & Matheus Dyczynski & Alexandra Leopoldi & Nicole Leeb & Jennifer V, 2023. "Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:550:y:2017:i:7674:d:10.1038_nature24027. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.