IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v549y2017i7673d10.1038_nature24018.html
   My bibliography  Save this article

Parental influence on human germline de novo mutations in 1,548 trios from Iceland

Author

Listed:
  • Hákon Jónsson

    (deCODE genetics/Amgen Inc.)

  • Patrick Sulem

    (deCODE genetics/Amgen Inc.)

  • Birte Kehr

    (deCODE genetics/Amgen Inc.)

  • Snaedis Kristmundsdottir

    (deCODE genetics/Amgen Inc.)

  • Florian Zink

    (deCODE genetics/Amgen Inc.)

  • Eirikur Hjartarson

    (deCODE genetics/Amgen Inc.)

  • Marteinn T. Hardarson

    (deCODE genetics/Amgen Inc.)

  • Kristjan E. Hjorleifsson

    (deCODE genetics/Amgen Inc.)

  • Hannes P. Eggertsson

    (deCODE genetics/Amgen Inc.)

  • Sigurjon Axel Gudjonsson

    (deCODE genetics/Amgen Inc.)

  • Lucas D. Ward

    (deCODE genetics/Amgen Inc.)

  • Gudny A. Arnadottir

    (deCODE genetics/Amgen Inc.)

  • Einar A. Helgason

    (deCODE genetics/Amgen Inc.)

  • Hannes Helgason

    (deCODE genetics/Amgen Inc.)

  • Arnaldur Gylfason

    (deCODE genetics/Amgen Inc.)

  • Adalbjorg Jonasdottir

    (deCODE genetics/Amgen Inc.)

  • Aslaug Jonasdottir

    (deCODE genetics/Amgen Inc.)

  • Thorunn Rafnar

    (deCODE genetics/Amgen Inc.)

  • Mike Frigge

    (deCODE genetics/Amgen Inc.)

  • Simon N. Stacey

    (deCODE genetics/Amgen Inc.)

  • Olafur Th. Magnusson

    (deCODE genetics/Amgen Inc.)

  • Unnur Thorsteinsdottir

    (deCODE genetics/Amgen Inc.
    Faculty of Medicine, School of Health Sciences, University of Iceland)

  • Gisli Masson

    (deCODE genetics/Amgen Inc.)

  • Augustine Kong

    (deCODE genetics/Amgen Inc.
    School of Engineering and Natural Sciences, University of Iceland)

  • Bjarni V. Halldorsson

    (deCODE genetics/Amgen Inc.
    School of Science and Engineering, Reykjavik University)

  • Agnar Helgason

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Daniel F. Gudbjartsson

    (deCODE genetics/Amgen Inc.
    School of Engineering and Natural Sciences, University of Iceland)

  • Kari Stefansson

    (deCODE genetics/Amgen Inc.
    Faculty of Medicine, School of Health Sciences, University of Iceland)

Abstract

Whole-genome sequencing data of 14,688 Icelanders, including 1,548 parent–offspring trios, show how the age and sex of parents affect the rate and spectrum of de novo mutations.

Suggested Citation

  • Hákon Jónsson & Patrick Sulem & Birte Kehr & Snaedis Kristmundsdottir & Florian Zink & Eirikur Hjartarson & Marteinn T. Hardarson & Kristjan E. Hjorleifsson & Hannes P. Eggertsson & Sigurjon Axel Gudj, 2017. "Parental influence on human germline de novo mutations in 1,548 trios from Iceland," Nature, Nature, vol. 549(7673), pages 519-522, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature24018
    DOI: 10.1038/nature24018
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24018
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature24018?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marie Bernkopf & Ummi B. Abdullah & Stephen J. Bush & Katherine A. Wood & Sahar Ghaffari & Eleni Giannoulatou & Nils Koelling & Geoffrey J. Maher & Loïc M. Thibaut & Jonathan Williams & Edward M. Blai, 2023. "Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature24018. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.