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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Author

Listed:
  • Yang Shi

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Kaoru Yamada

    (Graduate School of Medicine, The University of Tokyo)

  • Shane Antony Liddelow

    (School of Medicine, Stanford University
    The University of Melbourne, Melbourne)

  • Scott T. Smith

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Lingzhi Zhao

    (Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College of Cornell University)

  • Wenjie Luo

    (Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College of Cornell University)

  • Richard M. Tsai

    (Memory and Aging Center, University of California)

  • Salvatore Spina

    (Memory and Aging Center, University of California)

  • Lea T. Grinberg

    (Memory and Aging Center, University of California
    University of California)

  • Julio C. Rojas

    (Memory and Aging Center, University of California)

  • Gilbert Gallardo

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Kairuo Wang

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Joseph Roh

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Grace Robinson

    (University of Missouri School of Medicine)

  • Mary Beth Finn

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Hong Jiang

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Patrick M. Sullivan

    (Duke University Medical Center, Durham Veterans Health Administration Medical Center’s Geriatric Research, Education and Clinical Center)

  • Caroline Baufeld

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Michael W. Wood

    (AstraZeneca R&D)

  • Courtney Sutphen

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Lena McCue

    (Washington University in St Louis)

  • Chengjie Xiong

    (Washington University in St Louis)

  • Jorge L. Del-Aguila

    (Washington University School of Medicine)

  • John C. Morris

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Carlos Cruchaga

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Anne M. Fagan

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

  • Bruce L. Miller

    (Memory and Aging Center, University of California)

  • Adam L. Boxer

    (Memory and Aging Center, University of California)

  • William W. Seeley

    (Memory and Aging Center, University of California
    University of California)

  • Oleg Butovsky

    (Brigham and Women’s Hospital, Harvard Medical School
    Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Ben A. Barres

    (School of Medicine, Stanford University)

  • Steven M. Paul

    (Voyager Therapeutics)

  • David M. Holtzman

    (Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine)

Abstract

ApoE4 exacerbates tau pathogenesis, neuroinflammation and tau-mediated neurodegeneration independently of brain amyloid-β pathology, and exerts a ‘toxic’ gain of function whereas its absence is protective.

Suggested Citation

  • Yang Shi & Kaoru Yamada & Shane Antony Liddelow & Scott T. Smith & Lingzhi Zhao & Wenjie Luo & Richard M. Tsai & Salvatore Spina & Lea T. Grinberg & Julio C. Rojas & Gilbert Gallardo & Kairuo Wang & J, 2017. "ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy," Nature, Nature, vol. 549(7673), pages 523-527, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature24016
    DOI: 10.1038/nature24016
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    Cited by:

    1. Inbal Maniv & Mahasen Sarji & Anwar Bdarneh & Alona Feldman & Roi Ankawa & Elle Koren & Inbar Magid-Gold & Noa Reis & Despina Soteriou & Shiran Salomon-Zimri & Tali Lavy & Ellina Kesselman & Naama Koi, 2023. "Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Jiyeon Lee & Julie M. Dimitry & Jong Hee Song & Minsoo Son & Patrick W. Sheehan & Melvin W. King & G. Travis Tabor & Young Ah Goo & Mitchell A. Lazar & Leonard Petrucelli & Erik S. Musiek, 2023. "Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Hideyuki Takahashi & Sanaea Bhagwagar & Sarah H. Nies & Hongping Ye & Xianlin Han & Marius T. Chiasseu & Guilin Wang & Ian R. Mackenzie & Stephen M. Strittmatter, 2024. "Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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