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Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Author

Listed:
  • Zachary D. Smith

    (Broad Institute of MIT and Harvard
    Harvard University
    Harvard University)

  • Jiantao Shi

    (Dana-Farber Cancer Institute
    Harvard T. H. Chan School of Public Health)

  • Hongcang Gu

    (Broad Institute of MIT and Harvard)

  • Julie Donaghey

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Kendell Clement

    (Broad Institute of MIT and Harvard
    Harvard University
    Harvard-MIT Division of Health Sciences and Technology)

  • Davide Cacchiarelli

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Andreas Gnirke

    (Broad Institute of MIT and Harvard)

  • Franziska Michor

    (Broad Institute of MIT and Harvard
    Harvard University
    Dana-Farber Cancer Institute
    Harvard T. H. Chan School of Public Health)

  • Alexander Meissner

    (Broad Institute of MIT and Harvard
    Harvard University
    Max Planck Institute for Molecular Genetics)

Abstract

Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

Suggested Citation

  • Zachary D. Smith & Jiantao Shi & Hongcang Gu & Julie Donaghey & Kendell Clement & Davide Cacchiarelli & Andreas Gnirke & Franziska Michor & Alexander Meissner, 2017. "Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer," Nature, Nature, vol. 549(7673), pages 543-547, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature23891
    DOI: 10.1038/nature23891
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    Cited by:

    1. Simon Andrews & Christel Krueger & Maravillas Mellado-Lopez & Myriam Hemberger & Wendy Dean & Vicente Perez-Garcia & Courtney W. Hanna, 2023. "Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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