IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v549y2017i7673d10.1038_nature23882.html
   My bibliography  Save this article

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

Author

Listed:
  • Masao Ohashi

    (University of California, Los Angeles
    University of Shizuoka)

  • Fang Liu

    (University of California, Los Angeles)

  • Yang Hai

    (University of California, Los Angeles)

  • Mengbin Chen

    (University of California, Los Angeles)

  • Man-cheng Tang

    (University of California, Los Angeles)

  • Zhongyue Yang

    (University of California, Los Angeles)

  • Michio Sato

    (University of California, Los Angeles
    University of Shizuoka)

  • Kenji Watanabe

    (University of Shizuoka)

  • K. N. Houk

    (University of California, Los Angeles
    University of California, Los Angeles)

  • Yi Tang

    (University of California, Los Angeles
    University of California, Los Angeles)

Abstract

The enzyme LepI is found to be capable of catalysing several natural-product pericyclic transformations, including a hetero-Diels–Alder reaction and a retro-Claisen rearrangement.

Suggested Citation

  • Masao Ohashi & Fang Liu & Yang Hai & Mengbin Chen & Man-cheng Tang & Zhongyue Yang & Michio Sato & Kenji Watanabe & K. N. Houk & Yi Tang, 2017. "SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis," Nature, Nature, vol. 549(7673), pages 502-506, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature23882
    DOI: 10.1038/nature23882
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature23882
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature23882?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qi Ding & Nianxin Guo & Lei Gao & Michelle McKee & Dongshan Wu & Jun Yang & Junping Fan & Jing-Ke Weng & Xiaoguang Lei, 2024. "The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Yuchun Zhao & Xiangyang Liu & Zhihong Xiao & Jie Zhou & Xingyu Song & Xiaozheng Wang & Lijun Hu & Ying Wang & Peng Sun & Wenning Wang & Xinyi He & Shuangjun Lin & Zixin Deng & Lifeng Pan & Ming Jiang, 2023. "O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature23882. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.