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Palmitoylation-dependent activation of MC1R prevents melanomagenesis

Author

Listed:
  • Shuyang Chen

    (Boston University School of Medicine)

  • Bo Zhu

    (Boston University School of Medicine)

  • Chengqian Yin

    (Boston University School of Medicine)

  • Wei Liu

    (Boston University School of Medicine)

  • Changpeng Han

    (Boston University School of Medicine)

  • Baoen Chen

    (Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Tongzheng Liu

    (Jinan University Institute of Tumor Pharmacology)

  • Xin Li

    (Boston University School of Medicine)

  • Xiang Chen

    (Xiangya Hospital, Central South University)

  • Chunying Li

    (Xijing Hospital, The Fourth Military Medical University)

  • Limin Hu

    (Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine)

  • Jun Zhou

    (State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University)

  • Zhi-Xiang Xu

    (Comprehensive Cancer Center, University of Alabama at Birmingham)

  • Xiumei Gao

    (Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine)

  • Xu Wu

    (Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Colin R. Goding

    (Ludwig Institute for Cancer Research, University of Oxford)

  • Rutao Cui

    (Boston University School of Medicine)

Abstract

The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.

Suggested Citation

  • Shuyang Chen & Bo Zhu & Chengqian Yin & Wei Liu & Changpeng Han & Baoen Chen & Tongzheng Liu & Xin Li & Xiang Chen & Chunying Li & Limin Hu & Jun Zhou & Zhi-Xiang Xu & Xiumei Gao & Xu Wu & Colin R. Go, 2017. "Palmitoylation-dependent activation of MC1R prevents melanomagenesis," Nature, Nature, vol. 549(7672), pages 399-403, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7672:d:10.1038_nature23887
    DOI: 10.1038/nature23887
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    Cited by:

    1. Do-Won Jeong & Jong-Wan Park & Kyeong Seog Kim & Jiyoung Kim & June Huh & Jieun Seo & Ye Lee Kim & Joo-Youn Cho & Kwang-Woong Lee & Junji Fukuda & Yang-Sook Chun, 2023. "Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Keisuke Tabata & Kenta Imai & Koki Fukuda & Kentaro Yamamoto & Hayato Kunugi & Toshiharu Fujita & Tatsuya Kaminishi & Christian Tischer & Beate Neumann & Sabine Reither & Fatima Verissimo & Rainer Pep, 2024. "Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Hai Ni & Yinuo Wang & Kai Yao & Ling Wang & Jiancheng Huang & Yongfang Xiao & Hongyao Chen & Bo Liu & Cliff Y. Yang & Jijun Zhao, 2024. "Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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