IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v549y2017i7672d10.1038_nature23672.html
   My bibliography  Save this article

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease

Author

Listed:
  • Elvira Mass

    (Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center)

  • Christian E. Jacome-Galarza

    (Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center)

  • Thomas Blank

    (Institute of Neuropathology, Faculty of Medicine, BIOSS Centre for Biological Signalling Studies, University of Freiburg)

  • Tomi Lazarov

    (Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center)

  • Benjamin H. Durham

    (Human Oncology and Pathogenesis Program, Leukemia Service, Memorial Sloan Kettering Cancer Center)

  • Neval Ozkaya

    (Memorial Sloan Kettering Cancer Center)

  • Alessandro Pastore

    (Human Oncology and Pathogenesis Program, Leukemia Service, Memorial Sloan Kettering Cancer Center)

  • Marius Schwabenland

    (Institute of Neuropathology, Faculty of Medicine, BIOSS Centre for Biological Signalling Studies, University of Freiburg)

  • Young Rock Chung

    (Human Oncology and Pathogenesis Program, Leukemia Service, Memorial Sloan Kettering Cancer Center)

  • Marc K. Rosenblum

    (Memorial Sloan Kettering Cancer Center)

  • Marco Prinz

    (Institute of Neuropathology, Faculty of Medicine, BIOSS Centre for Biological Signalling Studies, University of Freiburg)

  • Omar Abdel-Wahab

    (Human Oncology and Pathogenesis Program, Leukemia Service, Memorial Sloan Kettering Cancer Center)

  • Frederic Geissmann

    (Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
    Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London)

Abstract

Braf V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.

Suggested Citation

  • Elvira Mass & Christian E. Jacome-Galarza & Thomas Blank & Tomi Lazarov & Benjamin H. Durham & Neval Ozkaya & Alessandro Pastore & Marius Schwabenland & Young Rock Chung & Marc K. Rosenblum & Marco Pr, 2017. "A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease," Nature, Nature, vol. 549(7672), pages 389-393, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7672:d:10.1038_nature23672
    DOI: 10.1038/nature23672
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature23672
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature23672?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:549:y:2017:i:7672:d:10.1038_nature23672. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.