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Polycomb-like proteins link the PRC2 complex to CpG islands

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Listed:
  • Haojie Li

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

  • Robert Liefke

    (Boston Children’s Hospital
    Harvard Medical School)

  • Junyi Jiang

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

  • Jesse Vigoda Kurland

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Wei Tian

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

  • Pujuan Deng

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

  • Weidi Zhang

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

  • Qian He

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Martha L. Bulyk

    (Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School)

  • Yang Shi

    (Boston Children’s Hospital
    Harvard Medical School)

  • Zhanxin Wang

    (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University)

Abstract

Crystal structures of the Polycomb-like proteins PHF1 and MTF2 with bound DNA and histone peptides show that extended homologous regions of the two proteins form a winged-helix structure that has an unexpected mechanism of binding to unmethylated CpG-containing DNA motifs.

Suggested Citation

  • Haojie Li & Robert Liefke & Junyi Jiang & Jesse Vigoda Kurland & Wei Tian & Pujuan Deng & Weidi Zhang & Qian He & Dinshaw J. Patel & Martha L. Bulyk & Yang Shi & Zhanxin Wang, 2017. "Polycomb-like proteins link the PRC2 complex to CpG islands," Nature, Nature, vol. 549(7671), pages 287-291, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7671:d:10.1038_nature23881
    DOI: 10.1038/nature23881
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    Cited by:

    1. Daniel Bsteh & Hagar F. Moussa & Georg Michlits & Ramesh Yelagandula & Jingkui Wang & Ulrich Elling & Oliver Bell, 2023. "Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Chet H. Loh & Siebe Genesen & Matteo Perino & Magnus R. Bark & Gert Jan C. Veenstra, 2021. "Loss of PRC2 subunits primes lineage choice during exit of pluripotency," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Mengwen Hu & Yu-Han Yeh & Yasuhisa Munakata & Hironori Abe & Akihiko Sakashita & So Maezawa & Miguel Vidal & Haruhiko Koseki & Neil Hunter & Richard M. Schultz & Satoshi H. Namekawa, 2022. "PRC1-mediated epigenetic programming is required to generate the ovarian reserve," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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