IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v549y2017i7671d10.1038_nature23676.html
   My bibliography  Save this article

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Author

Listed:
  • Christoph S. N. Klose

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Tanel Mahlakõiv

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Jesper B. Moeller

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
    University of Southern Denmark)

  • Lucille C. Rankin

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Anne-Laure Flamar

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Hiroki Kabata

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Laurel A. Monticelli

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Saya Moriyama

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Gregory Garbès Putzel

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

  • Nikolai Rakhilin

    (Duke University
    School of Electrical and Computer Engineering, Cornell University)

  • Xiling Shen

    (Duke University
    School of Electrical and Computer Engineering, Cornell University)

  • Evi Kostenis

    (Institute of Pharmaceutical Biology, University of Bonn)

  • Gabriele M. König

    (Institute of Pharmaceutical Biology, University of Bonn)

  • Takashi Senda

    (Columbia University Medical Center
    Columbia University Medical Center)

  • Dustin Carpenter

    (Columbia University Medical Center
    Columbia University Medical Center)

  • Donna L. Farber

    (Columbia University Medical Center
    Columbia University Medical Center)

  • David Artis

    (Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University)

Abstract

Intestinal type 2 innate lymphoid cells express the neuropeptide receptor NMUR1, which makes them responsive to neuronal neuromedin U, thereby promoting a type 2 cytokine response and accelerated expulsion of the gastro-intestinal nematode Nippostrongylus brasiliensis.

Suggested Citation

  • Christoph S. N. Klose & Tanel Mahlakõiv & Jesper B. Moeller & Lucille C. Rankin & Anne-Laure Flamar & Hiroki Kabata & Laurel A. Monticelli & Saya Moriyama & Gregory Garbès Putzel & Nikolai Rakhilin & , 2017. "The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation," Nature, Nature, vol. 549(7671), pages 282-286, September.
  • Handle: RePEc:nat:nature:v:549:y:2017:i:7671:d:10.1038_nature23676
    DOI: 10.1038/nature23676
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature23676
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature23676?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:549:y:2017:i:7671:d:10.1038_nature23676. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.