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Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Author

Listed:
  • Riccardo Mezzadra

    (The Netherlands Cancer Institute)

  • Chong Sun

    (The Netherlands Cancer Institute)

  • Lucas T. Jae

    (The Netherlands Cancer Institute
    Ludwig-Maximilians-Universität München)

  • Raquel Gomez-Eerland

    (The Netherlands Cancer Institute)

  • Evert de Vries

    (The Netherlands Cancer Institute)

  • Wei Wu

    (Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
    Netherlands Proteomics Centre)

  • Meike E. W. Logtenberg

    (The Netherlands Cancer Institute)

  • Maarten Slagter

    (The Netherlands Cancer Institute
    The Netherlands Cancer Institute)

  • Elisa A. Rozeman

    (The Netherlands Cancer Institute
    The Netherlands Cancer Institute)

  • Ingrid Hofland

    (Core Facility Molecular Pathology & Biobanking, The Netherlands Cancer Institute)

  • Annegien Broeks

    (Core Facility Molecular Pathology & Biobanking, The Netherlands Cancer Institute)

  • Hugo M. Horlings

    (The Netherlands Cancer Institute)

  • Lodewyk F. A. Wessels

    (The Netherlands Cancer Institute)

  • Christian U. Blank

    (The Netherlands Cancer Institute
    The Netherlands Cancer Institute)

  • Yanling Xiao

    (The Netherlands Cancer Institute)

  • Albert J. R. Heck

    (Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
    Netherlands Proteomics Centre)

  • Jannie Borst

    (The Netherlands Cancer Institute)

  • Thijn R. Brummelkamp

    (The Netherlands Cancer Institute
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    Cancergenomics.nl)

  • Ton N. M. Schumacher

    (The Netherlands Cancer Institute)

Abstract

CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells.

Suggested Citation

  • Riccardo Mezzadra & Chong Sun & Lucas T. Jae & Raquel Gomez-Eerland & Evert de Vries & Wei Wu & Meike E. W. Logtenberg & Maarten Slagter & Elisa A. Rozeman & Ingrid Hofland & Annegien Broeks & Hugo M., 2017. "Identification of CMTM6 and CMTM4 as PD-L1 protein regulators," Nature, Nature, vol. 549(7670), pages 106-110, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7670:d:10.1038_nature23669
    DOI: 10.1038/nature23669
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    Cited by:

    1. Di-Ao Liu & Kai Tao & Bin Wu & Ziyan Yu & Malwina Szczepaniak & Matthew Rames & Changsong Yang & Tatyana Svitkina & Yueyao Zhu & Fengyuan Xu & Xiaolin Nan & Wei Guo, 2023. "A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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