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Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Author

Listed:
  • Kathrin Pieper

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Joshua Tan

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    University of Oxford, John Radcliffe Hospital)

  • Luca Piccoli

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Mathilde Foglierini

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Swiss Institute of Bioinformatics (SIB))

  • Sonia Barbieri

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Yiwei Chen

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Institute for Microbiology, ETH Zurich)

  • Chiara Silacci-Fregni

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Tobias Wolf

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Institute for Microbiology, ETH Zurich)

  • David Jarrossay

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Marica Anderle

    (Institute for Research in Biomedicine, Università della Svizzera Italiana)

  • Abdirahman Abdi

    (KEMRI-Wellcome Trust Research Programme)

  • Francis M. Ndungu

    (KEMRI-Wellcome Trust Research Programme)

  • Ogobara K. Doumbo

    (Malaria Research and Training Centre, University of Sciences, Technique, and Technology of Bamako)

  • Boubacar Traore

    (Malaria Research and Training Centre, University of Sciences, Technique, and Technology of Bamako)

  • Tuan M. Tran

    (Indiana University School of Medicine)

  • Said Jongo

    (Ifakara Health Institute, Bagamoyo Clinical Trial Unit)

  • Isabelle Zenklusen

    (Swiss Tropical and Public Health Institute, Clinical Immunology Unit
    University of Basel)

  • Peter D. Crompton

    (Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Claudia Daubenberger

    (Swiss Tropical and Public Health Institute, Clinical Immunology Unit
    University of Basel)

  • Peter C. Bull

    (University of Cambridge)

  • Federica Sallusto

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Institute for Microbiology, ETH Zurich)

  • Antonio Lanzavecchia

    (Institute for Research in Biomedicine, Università della Svizzera Italiana
    Institute for Microbiology, ETH Zurich)

Abstract

Up to 10% of individuals in malaria-endemic regions produce antibodies that react to malaria antigens through an additional LAIR1 domain that is inserted by two different insertion modalities.

Suggested Citation

  • Kathrin Pieper & Joshua Tan & Luca Piccoli & Mathilde Foglierini & Sonia Barbieri & Yiwei Chen & Chiara Silacci-Fregni & Tobias Wolf & David Jarrossay & Marica Anderle & Abdirahman Abdi & Francis M. N, 2017. "Public antibodies to malaria antigens generated by two LAIR1 insertion modalities," Nature, Nature, vol. 548(7669), pages 597-601, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7669:d:10.1038_nature23670
    DOI: 10.1038/nature23670
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