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Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

Author

Listed:
  • Kai Yang

    (St Jude Children’s Research Hospital)

  • Daniel Bastardo Blanco

    (St Jude Children’s Research Hospital)

  • Geoffrey Neale

    (Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital)

  • Peter Vogel

    (St Jude Children’s Research Hospital)

  • Julian Avila

    (Metabolomics Platform, Broad Institute of MIT and Harvard University)

  • Clary B. Clish

    (Metabolomics Platform, Broad Institute of MIT and Harvard University)

  • Chuan Wu

    (Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Sharad Shrestha

    (St Jude Children’s Research Hospital)

  • Sherri Rankin

    (St Jude Children’s Research Hospital)

  • Lingyun Long

    (St Jude Children’s Research Hospital)

  • Anil KC

    (St Jude Children’s Research Hospital)

  • Hongbo Chi

    (St Jude Children’s Research Hospital)

Abstract

The tumour suppressor liver kinase B1 (LKB1) regulates the metabolic and functional fitness of regulatory T cells in the control of immune tolerance and homeostasis.

Suggested Citation

  • Kai Yang & Daniel Bastardo Blanco & Geoffrey Neale & Peter Vogel & Julian Avila & Clary B. Clish & Chuan Wu & Sharad Shrestha & Sherri Rankin & Lingyun Long & Anil KC & Hongbo Chi, 2017. "Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling," Nature, Nature, vol. 548(7669), pages 602-606, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7669:d:10.1038_nature23665
    DOI: 10.1038/nature23665
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    Cited by:

    1. Di Wu & Haomin Li & Mingwei Liu & Jun Qin & Yi Sun, 2022. "The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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