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Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

Author

Listed:
  • Tetsuhiro Kikuchi

    (Center for iPS Cell Research and Application, Kyoto University)

  • Asuka Morizane

    (Center for iPS Cell Research and Application, Kyoto University)

  • Daisuke Doi

    (Center for iPS Cell Research and Application, Kyoto University)

  • Hiroaki Magotani

    (Center for iPS Cell Research and Application, Kyoto University)

  • Hirotaka Onoe

    (RIKEN Center for Life Science Technologies)

  • Takuya Hayashi

    (RIKEN Center for Life Science Technologies)

  • Hiroshi Mizuma

    (RIKEN Center for Life Science Technologies)

  • Sayuki Takara

    (RIKEN Center for Life Science Technologies)

  • Ryosuke Takahashi

    (Kyoto University Graduate School of Medicine)

  • Haruhisa Inoue

    (Center for iPS Cell Research and Application, Kyoto University)

  • Satoshi Morita

    (Kyoto University Graduate School of Medicine)

  • Michio Yamamoto

    (Kyoto University Graduate School of Medicine)

  • Keisuke Okita

    (Center for iPS Cell Research and Application, Kyoto University)

  • Masato Nakagawa

    (Center for iPS Cell Research and Application, Kyoto University)

  • Malin Parmar

    (Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University)

  • Jun Takahashi

    (Center for iPS Cell Research and Application, Kyoto University
    Clinical Neuroscience, Graduate School of Medicine, Kyoto University)

Abstract

In a preclinical study, dopaminergic neurons derived from human induced pluripotent stem cells were implanted into a primate model of Parkinson’s disease, where they were found to exhibit long-term survival, function as mid-brain dopaminergic neurons, and increase spontaneous movements.

Suggested Citation

  • Tetsuhiro Kikuchi & Asuka Morizane & Daisuke Doi & Hiroaki Magotani & Hirotaka Onoe & Takuya Hayashi & Hiroshi Mizuma & Sayuki Takara & Ryosuke Takahashi & Haruhisa Inoue & Satoshi Morita & Michio Yam, 2017. "Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model," Nature, Nature, vol. 548(7669), pages 592-596, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7669:d:10.1038_nature23664
    DOI: 10.1038/nature23664
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