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Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

Author

Listed:
  • Weike Pei

    (German Cancer Research Center)

  • Thorsten B. Feyerabend

    (German Cancer Research Center)

  • Jens Rössler

    (German Cancer Research Center)

  • Xi Wang

    (German Cancer Research Center
    Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH))

  • Daniel Postrach

    (German Cancer Research Center)

  • Katrin Busch

    (German Cancer Research Center)

  • Immanuel Rode

    (German Cancer Research Center)

  • Kay Klapproth

    (German Cancer Research Center)

  • Nikolaus Dietlein

    (German Cancer Research Center)

  • Claudia Quedenau

    (Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH))

  • Wei Chen

    (Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH))

  • Sascha Sauer

    (Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH))

  • Stephan Wolf

    (Genomics & Proteomics Core Facilities, German Cancer Research Center)

  • Thomas Höfer

    (German Cancer Research Center
    Bioquant Center, University of Heidelberg)

  • Hans-Reimer Rodewald

    (German Cancer Research Center)

Abstract

An artificial recombination locus, Polylox, that can generate hundreds of thousands of individual barcodes is used to trace the fates of haematopoietic stem cells in mice.

Suggested Citation

  • Weike Pei & Thorsten B. Feyerabend & Jens Rössler & Xi Wang & Daniel Postrach & Katrin Busch & Immanuel Rode & Kay Klapproth & Nikolaus Dietlein & Claudia Quedenau & Wei Chen & Sascha Sauer & Stephan , 2017. "Polylox barcoding reveals haematopoietic stem cell fates realized in vivo," Nature, Nature, vol. 548(7668), pages 456-460, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7668:d:10.1038_nature23653
    DOI: 10.1038/nature23653
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    Cited by:

    1. Mina N. F. Morcos & Congxin Li & Clara M. Munz & Alessandro Greco & Nicole Dressel & Susanne Reinhardt & Katrin Sameith & Andreas Dahl & Nils B. Becker & Axel Roers & Thomas Höfer & Alexander Gerbaule, 2022. "Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. C. Biben & T. S. Weber & K. S. Potts & J. Choi & D. C. Miles & A. Carmagnac & T. Sargeant & C. A. Graaf & K. A. Fennell & A. Farley & O. J. Stonehouse & M. A. Dawson & D. J. Hilton & S. H. Naik & S. T, 2023. "In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Sara Ballouz & Risa Karakida Kawaguchi & Maria T. Pena & Stephan Fischer & Megan Crow & Leon French & Frank M. Knight & Linda B. Adams & Jesse Gillis, 2023. "The transcriptional legacy of developmental stochasticity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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